Evidence map›Paper›PMID 26849006›Full record

ReviewCurrent opinion in pediatrics2016

Renal dysplasia in the neonate.

Yu L Phua, Jacqueline Ho

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Renal dysplasia in horses: 25 cases (1991-2021).Journal of veterinary internal medicine · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yu L PhuaaRangos Research Center, Children's Hospital of Pittsburgh of UPMC bDepartment of Pediatrics, Division of Nephrology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jacqueline Ho
Children's Hospital of Pittsburgh · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
The Role of miR-17~92 in Nephron ProgenitorsR01DK103776 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2014 to 2018
$1.7M
MicroRNAs in Kidney Progenitor Cells.R00DK087922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2012 to 2014
$722k
NIDDK NIH HHS DK076169NIDDK NIH HHS R00 DK087922NIDDK NIH HHS R00DK087922NIDDK NIH HHS R01 DK103776NIDDK NIH HHS R01DK103776NIDDK NIH HHS U24 DK076169
6 · The paper itself

Abstract

purpose of reviewRenal dysplasia is classically described as a developmental disorder whereby the kidneys fail to undergo appropriate differentiation, resulting in the presence of malformed renal tissue elements. It is the commonest cause of chronic kidney disease and renal failure in the neonate. Although several genes have been identified in association with renal dysplasia, the underlying molecular mechanisms are often complex and heterogeneous in nature, and remain poorly understood. RECENT

findingsIn this review, we describe new insights into the fundamental process of normal kidney development, and how the renal cortex and medulla are patterned appropriately during gestation. We review the key genes that are indispensable for this process, and discuss how patterning of the kidney is perturbed in the absence of these signaling pathways. The recent use of whole exome sequencing has identified genetic mutations in patients with renal dysplasia, and the results of these studies have increased our understanding of the pathophysiology of renal dysplasia. SUMMARY: At present, there are no specific treatments available for patients with renal dysplasia. Understanding the molecular mechanisms of normal kidney development and the pathogenesis of renal dysplasia may allow for improved therapeutic options for these patients.

Indexed as

AnimalsBody PatterningDisease Models, AnimalExomeHumansInfant, NewbornKidneyMice, TransgenicMutationNephronsOrganogenesisUrinary Tract

Identifiers

PMID26849006
PMCPMC4809249
OpenAlexW2321423793

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.