ArticlePloS one2016
Adjusted Age-Adjusted Charlson Comorbidity Index Score as a Risk Measure of Perioperative Mortality before Cancer Surgery.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers, 2 of them syntheses that pooled it.
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Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic utility of the Charlson comorbidity index in pancreatic cancer: a systematic review and meta‑analysis.World journal of surgical oncology · 2026Pooled it
- Pooled it
- Intraoperative use of tranexamic acid to reduce blood loss during cytoreductive surgery for advanced ovarian cancer: A randomized controlled clinical trial.Acta obstetricia et gynecologica Scandinavica · 2023Trial
- A randomized controlled trial of stapled versus ultrasonic transection in distal pancreatectomy.Surgical endoscopy · 2022Trial
- Surgical site infection after open versus minimally invasive left pancreatectomy: a retrospective cohort study.Surgical endoscopy · 2026Article
- Observational
- Topical Pregabalin in Burning Mouth Syndrome: A Real-World Study of Peripheral Neuromodulation.Medicina (Kaunas, Lithuania) · 2026Article
- Comparison of the recovery profiles of remimazolam-remifentanil and propofol-remifentanil in older patients undergoing laparoscopic abdominal surgeries.Anesthesia and pain medicine · 2026Article
- Robotic versus laparoscopic pancreaticoduodenectomy: a propensity score matching analysis of Taiwan's national health insurance database.BMC surgery · 2026Article
- Predictors of postoperative complications in elderly patients undergoing pulmonary lobectomy: a retrospective cohort study.Frontiers in medicine · 2026Article
- Exploratory evaluation of combined handgrip strength and Age-Adjusted Charlson Comorbidity Index for prognosis in patients with primary liver cancer undergoing hepatectomy: a single-centre pilot study.Frontiers in medicine · 2026Article
- Overcoming the data barrier: transfer learning for 90-day mortality prediction in general surgery - a retrospective multicenter development and comparison study.International journal of surgery (London, England) · 2026Article
- Data imputation and domain-adaptive prediction of 1-year postoperative mortality in geriatric hip fracture patients following arthroplasty from multi-center study.International journal of surgery (London, England) · 2026Article
- Comparison of thoracic epidural anesthesia with an erector spinae plane infusion for post-esophagectomy analgesia: a pragmatic retrospective cohort study.Journal of thoracic disease · 2025Article
- Charlson-Deyo Index Impact on Overall Survival After Surgery for Sinonasal Squamous Cell Carcinoma.Laryngoscope investigative otolaryngology · 2025Article
- Integrating Multimorbidity Assessment into Rheumatology Care: Prognostic Role of the Charlson Comorbidity Index in Systemic Lupus Erythematosus.Healthcare (Basel, Switzerland) · 2025Review
- Clinical Frailty Scale predicts overall survival after colon cancer surgery in people aged 80 years and older: A prospective multicentre observational study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Observational
- Robotic versus laparoscopic anterior resection: comparative short-term outcomes in a propensity score matched cohort.Journal of robotic surgery · 2025Article
- Stereotactic body radiotherapy for single and multiple early-stage non-small cell lung cancer in patients aged ≥ 80 years.Radiation oncology (London, England) · 2025Article
- Association between Preoperative Exercise Tolerance, Comorbidities, and Survival Rates in Patients with Pancreatic Cancer.JMA journal · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentification of patients at risk of death from cancer surgery should aid in preoperative preparation. The purpose of this study is to assess and adjust the age-adjusted Charlson comorbidity index (ACCI) to identify cancer patients with increased risk of perioperative mortality.
methodsWe identified 156,151 patients undergoing surgery for one of the ten common cancers between 2007 and 2011 in the Taiwan National Health Insurance Research Database. Half of the patients were randomly selected, and a multivariate logistic regression analysis was used to develop an adjusted-ACCI score for estimating the risk of 90-day mortality by variables from the original ACCI. The score was validated. The association between the score and perioperative mortality was analyzed.
resultsThe adjusted-ACCI score yield a better discrimination on mortality after cancer surgery than the original ACCI score, with c-statics of 0.75 versus 0.71. Over 80 years of age, 70-80 years, and renal disease had the strongest impact on mortality, hazard ratios 8.40, 3.63, and 3.09 (P < 0.001), respectively. The overall 90-day mortality rates in the entire cohort varied from 0.9%, 2.9%, 7.0%, and 13.2% in four risk groups stratifying by the adjusted-ACCI score; the adjusted hazard ratio for score 4-7, 8-11, and ≥ 12 was 2.84, 6.07, and 11.17 (P < 0.001), respectively, in 90-day mortality compared to score 0-3.
conclusionsThe adjusted-ACCI score helps to identify patients with a higher risk of 90-day mortality after cancer surgery. It might be particularly helpful for preoperative evaluation of patients over 80 years of age.
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