Evidence map›Paper›PMID 26848595›Full record

ArticleInorganic chemistry2016

Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins.

Zachary L Rodgers, Thomas A Shell, Alexander M Brugh, Hannah L Nowotarski, Malcolm D E Forbes, David S Lawrence

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganic chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Vitamin BMolecules (Basel, Switzerland) · 2022
    Review
  2. Article
  3. Article
  4. Visible Light-Induced Radical Mediated DNA Damage.Photochemistry and photobiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary L RodgersDepartment of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
Thomas A ShellDepartment of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
Alexander M BrughDepartment of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
Hannah L NowotarskiDepartment of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
Malcolm D E ForbesDepartment of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
David S LawrenceDepartment of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and §Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

Funding

SYNTHETIC REGULATORS OF TYROSINE PROTEIN KINASESR01CA079954 · NCI · YESHIVA UNIVERSITY · PI LAWRENCE, DAVID S. · 1999 to 2016
$4.2M
NCI NIH HHS R01 CA079954NCI NIH HHS R01 CA79954
6 · The paper itself

Abstract

Cobalamins are known to react with thiols to yield stable β-axial Co(III)-S bonded thiolato-cobalamin complexes. However, in stark contrast to the Co-C bond in alkylcobalamins, the photolability of the Co-S bond in thiolato-cobalamins remains undetermined. We have investigated the photolysis of N-acetylcysteinyl cob(III)alamin at several wavelengths within the ultraviolet and visible spectrum. To aid in photolysis, we show that attaching fluorophore "antennae" to the cobalamin scaffold can improve photolytic efficiency by up to an order of magnitude. Additionally, electron paramagnetic resonance confirms previous conjectures that the photolysis of thiolato-cobalamins at wavelengths as long as 546 nm produces thiyl radicals.

Indexed as

PhotolysisChromatography, LiquidElectron Spin Resonance SpectroscopyFluorescent DyesProton Magnetic Resonance SpectroscopySpectrometry, Mass, Electrospray IonizationSulfhydryl CompoundsVitamin B 12Fluorescent DyesSulfhydryl CompoundsVitamin B 12

Identifiers

PMID26848595
PMCPMC5238438

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.