ArticlePloS one2016
Presynaptic GABAB Receptors Regulate Hippocampal Synapses during Associative Learning in Behaving Mice.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Impaired long-term depression mediated by group I metabotropic glutamate receptors, but not muscarinic acetylcholine receptors in juvenile-onset diabetes rats.IBRO neuroscience reports · 2026Article
- Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons.The Journal of physiology · 2026Article
- GABAFrontiers in pharmacology · 2026Review
- G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Presynaptic GABAPsychopharmacology · 2021Article
- Nicotine abolishes memory-related synaptic strengthening and promotes synaptic depression in the neurogenic dentate gyrus of miR-132/212 knockout mice.Addiction biology · 2021Article
- Sex- and age-related changes in GABA signaling components in the human cortex.Biology of sex differences · 2019Article
- Isolated seizures are a common early feature of paraneoplastic anti-GABAJournal of neurology · 2019Observational
- Robust Network Inhibition and Decay of Early-Phase LTP in the Hippocampal CA1 Subfield of the Amazon RodentFrontiers in neural circuits · 2018Article
- The interaction between hippocampal GABA-B and cannabinoid receptors upon spatial change and object novelty discrimination memory function.Psychopharmacology · 2017Article
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- Functional states of rat cortical circuits during the unpredictable availability of a reward-related cue.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABAB receptors are the G-protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the central nervous system. Pharmacological activation of GABAB receptors regulates neurotransmission and neuronal excitability at pre- and postsynaptic sites. Electrophysiological activation of GABAB receptors in brain slices generally requires strong stimulus intensities. This raises the question as to whether behavioral stimuli are strong enough to activate GABAB receptors. Here we show that GABAB1a-/- mice, which constitutively lack presynaptic GABAB receptors at glutamatergic synapses, are impaired in their ability to acquire an operant learning task. In vivo recordings during the operant conditioning reveal a deficit in learning-dependent increases in synaptic strength at CA3-CA1 synapses. Moreover, GABAB1a-/- mice fail to synchronize neuronal activity in the CA1 area during the acquisition process. Our results support that activation of presynaptic hippocampal GABAB receptors is important for acquisition of a learning task and for learning-associated synaptic changes and network dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.