ArticlePloS one2016
Global Metabolic Responses to Salt Stress in Fifteen Species.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Article
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- A Drought-Activated Bacterial Symbiont Enhances Legume Resilience Through Coordinated Amino Acid Metabolism.Microorganisms · 2026Article
- Metabolic response ofFrontiers in microbiology · 2026Article
- Common food preservatives induce an oxidative stress response inMicrobiology (Reading, England) · 2025Article
- Genomic adaptations of Vibrio campbellii to thermal and salinity stress: insights into marine pathogen resilience in a changing ocean.BMC genomics · 2025Article
- Low functional change despite high taxonomic turnover characterizes theScience advances · 2025Article
- Article
- Article
- In situ analysis of osmolyte mechanisms of proteome thermal stabilization.Nature chemical biology · 2024Article
- Wood Distillate Promotes the Tolerance of Lettuce in Extreme Salt Stress Conditions.Plants (Basel, Switzerland) · 2024Article
- Secondary metabolites with antimicrobial activity produced by thermophilic bacteria from a high-altitude hydrothermal system.Frontiers in microbiology · 2024Article
- Polyextremophile engineering: a review of organisms that push the limits of life.Frontiers in microbiology · 2024Review
- Engineering osmolysis susceptibility in Cupriavidus necator and Escherichia coli for recovery of intracellular products.Microbial cell factories · 2023Article
- Constitutive and Adaptive Traits of Environmental Stress Tolerance in the Threatened HalophytePlants (Basel, Switzerland) · 2022Article
- An Insight into Abiotic Stress and Influx Tolerance Mechanisms in Plants to Cope in Saline Environments.Biology · 2022Review
- Antibiotic tolerance in environmentally stressedmicroLife · 2022Article
- Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus.Nature microbiology · 2021Article
- Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution.Microbial cell factories · 2020Article
- Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis.Nature communications · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells constantly adapt to unpredictably changing extracellular solute concentrations. A cornerstone of the cellular osmotic stress response is the metabolic supply of energy and building blocks to mount appropriate defenses. Yet, the extent to which osmotic stress impinges on the metabolic network remains largely unknown. Moreover, it is mostly unclear which, if any, of the metabolic responses to osmotic stress are conserved among diverse organisms or confined to particular groups of species. Here we investigate the global metabolic responses of twelve bacteria, two yeasts and two human cell lines exposed to sustained hyperosmotic salt stress by measuring semiquantitative levels of hundreds of cellular metabolites using nontargeted metabolomics. Beyond the accumulation of osmoprotectants, we observed significant changes of numerous metabolites in all species. Global metabolic responses were predominantly species-specific, yet individual metabolites were characteristically affected depending on species' taxonomy, natural habitat, envelope structure or salt tolerance. Exploiting the breadth of our dataset, the correlation of individual metabolite response magnitudes across all species implicated lower glycolysis, tricarboxylic acid cycle, branched-chain amino acid metabolism and heme biosynthesis to be generally important for salt tolerance. Thus, our findings place the global metabolic salt stress response into a phylogenetic context and provide insights into the cellular phenotype associated with salt tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.