ArticlePloS one2016
Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The role of serum albumin inApplied and environmental microbiology · 2024Article
- Virulence Traits and Azole Resistance in KoreanJournal of fungi (Basel, Switzerland) · 2023Article
- Detection and Characterization of Two Phenotypes of Candida parapsilosis in South Korea: Clinical Features and Microbiological Findings.Microbiology spectrum · 2023Article
- Quantitative assay for farnesol and the aromatic fusel alcohols from the fungus Candida albicans.Applied microbiology and biotechnology · 2022Article
- Intraspecies heterogeneity in microbial interactions.Current opinion in microbiology · 2021Review
- A Predominance of Clade 17Frontiers in microbiology · 2019Article
- Multilocus Sequence Typing (MLST) Genotypes ofFrontiers in microbiology · 2018Article
- Disseminated Candidiasis in a Young, Previously Healthy, Dog and Review of Literature.Mycopathologia · 2017Review
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Authors and funding
12 authors.
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Abstract
Using multilocus sequence typing (MLST), Candida albicans can be subdivided into 18 different clades. Farnesol, a quorum-sensing molecule secreted by C. albicans, is thought to play an important role in the development of C. albicans biofilms and is also a virulence factor. This study evaluated whether C. albicans bloodstream infection (BSI) strains belonging to different MLST clades secrete different levels of E,E-farnesol (FOH) and whether they have different clinical characteristics. In total, 149 C. albicans BSI isolates from ten Korean hospitals belonging to clades 18 (n = 28), 4 (n = 23), 1 (n = 22), 12 (n = 17), and other clades (n = 59) were assessed. For each isolate, the FOH level in 24-hour biofilms was determined in filtered (0.45 μm) culture supernatant using high-performance liquid chromatography. Marked differences in FOH secretion from biofilms (0.10-6.99 μM) were observed among the 149 BSI isolates. Clade 18 isolates secreted significantly more FOH than did non-clade 18 isolates (mean ± SEM; 2.66 ± 0.22 vs. 1.69 ± 0.10 μM; P < 0.001). Patients with isolates belonging to clade 18 had a lower mean severity of illness than other patients, as measured using the "acute physiology and chronic health evaluation" (APACHE) III score (14.4 ± 1.1 vs. 18.0 ± 0.7; P < 0.05). This study provides evidence that C. albicans BSI isolates belonging to the most prevalent MLST clade (clade 18) in Korea are characterized by increased levels of FOH secretion and less severe illness.
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