ArticlePloS one2016
Visfatin Destabilizes Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Visfatin aggravates transverse aortic constriction-induced cardiac remodelling by enhancing macrophage-mediated oxidative stress in mice.Journal of cellular and molecular medicine · 2023Article
- Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker.Frontiers in immunology · 2023Review
- An Inducible and Vascular Smooth Muscle Cell-Specific Pink1 Knockout Induces Mitochondrial Energetic Dysfunction during Atherogenesis.International journal of molecular sciences · 2021Article
- Exploring the Pathogenesis of Psoriasis Complicated With AtherosclerosisFrontiers in immunology · 2021Article
- Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction.BMC cardiovascular disorders · 2020Article
- Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus.Frontiers in cardiovascular medicine · 2020Review
- Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis.Clinical science (London, England : 1979) · 2019Review
- Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2019Article
- Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunction.International journal of molecular medicine · 2018Article
- Long non-coding RNA Ftx promotes osteosarcoma progression via the epithelial to mesenchymal transition mechanism and is associated with poor prognosis in patients with osteosarcoma.International journal of clinical and experimental pathology · 2018Article
- Exploring the Crosstalk between Adipose Tissue and the Cardiovascular System.Korean circulation journal · 2017Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough there is evidence that visfatin is associated with atherogenesis, the effect of visfatin on plaque stability has not yet been explored.
methodsIn vivo, vulnerable plaques were established by carotid collar placement in apolipoprotein E-deficient (ApoE-/-) mice, and lentivirus expressing visfatin (lenti-visfatin) was locally infused in the carotid artery. The lipid, macrophage, smooth muscle cell (SMC) and collagen levels were evaluated, and the vulnerability index was calculated. In vitro, RAW264.7 cells were stimulated with visfatin, and the MMPs expressions were assessed by western blot and immunofluorescence. And the mechanism that involved in visfatin-induced MMP-8 production was investigated.
resultsTransfection with lenti-visfatin significantly promoted the expression of visfatin which mainly expressed in macrophages in the plaque. Lenti-visfatin transfection significantly promoted the accumulation of lipids and macrophages, modulated the phenotypes of smooth muscle cells and decreased the collagen levels in the plaques, which significantly decreased the plaque stability. Simultaneously, transfection with lenti-visfatin significantly up-regulated the expression of MMP-8 in vivo, as well as MMP-1, MMP-2 and MMP-9. Recombinant visfatin dose- and time-dependently up-regulated the in vitro expression of MMP-8 in macrophages. Visfatin promoted the translocation of NF-κB, and inhibition of NF-κB significantly reduced visfatin-induced MMP-8 production.
conclusionsVisfatin increased MMP-8 expression, promoted collagen degradation and increased the plaques vulnerability index.
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