ReviewCureus2015
Recent Advances and Review on Treatment of Stiff Person Syndrome in Adults and Pediatric Patients.
Review in Cureus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Phenotypic Spectrum, Diagnostic Challenges, and Clinical Outcomes in Stiff Person Syndrome: A Single-Center Case Series.Neurology international · 2026Article
- Case report of stiff - person syndrome and literature review.IBRO neuroscience reports · 2026Article
- Long-term neurological consequences following benzodiazepine exposure: A scoping review.PloS one · 2025Article
- The Effectiveness of Combining Botulinum Toxin Type A and Therapeutic Exercise in Treating Spasticity in a Patient with Complicated Stiff-Person Syndrome: A Case Report.Diseases (Basel, Switzerland) · 2024Article
- The IVIG treatment response in autoimmune polyendocrine syndromes type 2 with anti-GAD65 antibody-associated stiff person syndrome: a case report and literature review.Frontiers in immunology · 2024Review
- Stiff person syndrome in a Nepalese man with uncontrolled diabetes mellitus and ketonuria: A rare case report.Clinical case reports · 2023Article
- Therapeutic plasma exchange in the management of stiff person syndrome spectrum disorders: a case series and review of the literature.Therapeutic advances in neurological disorders · 2023Article
- Management of refractory pain in Stiff-Person syndrome.BMJ case reports · 2021Article
- The Interdisciplinary Stem Cell Institute's Use of Food and Drug Administration-Expanded Access Guidelines to Provide Experimental Cell Therapy to Patients With Rare Serious Diseases.Frontiers in cell and developmental biology · 2021Article
- [Stiff person syndrome associated with dermatitis herpetiformis: a case report].The Pan African medical journal · 2021Article
- Efficacy and safety of therapeutic plasma exchange in stiff person syndrome.Open medicine (Warsaw, Poland) · 2021Review
- Review
- Stiff-Person Syndrome Outpatient Rehabilitation: Case Report.Journal of neurosciences in rural practice · 2020Article
- Limited Utility for Benzodiazepines in Chronic Pain Management: A Narrative Review.Advances in therapy · 2020Review
- A high-throughput bioanalytical assay to support pharmacokinetic interaction study of oxycodone and diazepam in Sprague Dawley rats.RSC advances · 2020Article
- Effectiveness of Combined Immunoglobulin and Glucocorticoid Treatments in a Patient With Stiff Limb Syndrome: Case Report and Review of the Literature.Frontiers in neurology · 2020Article
- Article
- Article
- Association of stiff-person syndrome with autoimmune endocrine diseases.World journal of clinical cases · 2019Article
- Stiff Person Syndrome and Type 1 Diabetes Mellitus: a Case of the Chicken or the Egg?Journal of general internal medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stiff Person Syndrome (SPS) is one of the rarest autoimmune neurological disorders, which is mostly reported in women. It is characterised by fluctuating muscle rigidity and spasms. There are many variants of SPS, these include the classical SPS, Stiff Leg Syndrome (SLS), paraneoplastic variant, gait ataxia, dysarthria, and abnormal eye movements. Studies have shown that the paraneoplastic variant of SPS is more common in patients with breast cancer who harbour amphiphysin antibodies, followed by colon cancer, lung cancer, Hodgkin's disease, and malignant thymoma. Currently, the treatment for SPS revolves around improving the quality of life by reducing the symptoms as far as possible with the use of GABAergic agonists, such as diazepam or other benzodiazepines, steroids, plasmapheresis, and intravenous immunoglobulin (IVIG). There have been random clinical trials with Rituximab, but nothing concrete has been suggested. A treatment approach with standard drugs and cognitive behavioral therapy (CBT) seems to be promising.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.