ArticleIranian journal of pediatrics2016
Th1/Th2 Cytokine Profile and Its Diagnostic Value in Mycoplasma pneumoniae Pneumonia.
Article in Iranian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Azithromycin sequential therapy plus inhaled terbutaline for Mycoplasma Pneumoniae pneumonia in children: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Serum Tumor Necrosis Factor-Canadian respiratory journal · 2018Pooled it
- Effect of montelukast combined with methylprednisolone for the treatment of mycoplasma pneumonia.The Journal of international medical research · 2019Trial
- Development and validation of an explainable model for Mycoplasma pneumoniae infection in children.Scientific reports · 2026Article
- Network analysis of Mycoplasma pneumoniae pneumonia and Epstein-Barr virus co-infection.BMC infectious diseases · 2026Article
- The role of IFN-γ/CXCL10 axis in Mycoplasma pneumonia infection.Scientific reports · 2025Article
- Evaluating the role of interleukin-2 and interleukin-12 in pediatric patients with concurrentWorld journal of clinical cases · 2024Article
- Clinical characteristics and risk factors forFrontiers in pediatrics · 2024Article
- Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasma pneumoniae pneumonia.Journal of clinical laboratory analysis · 2019Article
- TheBioscience reports · 2019Article
- Ameliorative Effects of Infantile Feire Kechuan Oral Solution on Mycoplasma Pneumoniae Pneumonia in Infant Mouse and Rat Models.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Article
- Anti-inflammatory effects ofAmerican journal of translational research · 2016Article
- Relationships between Th1/Th2 cytokine profiles and chest radiographic manifestations in childhoodTherapeutics and clinical risk management · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe levels of Th1/Th2 cytokine can alter in pathogenic infection in children with pneumonia.
objectivesTo evaluate Th1/Th2 cytokine profile and its diagnostic value in M. pneumoniae pneumonia in children. PATIENTS AND
methodsChildren with M. pneumoniae mono-infection and 30 healthy children were tested with cytokines assay. We used real time PCR to detect M. pneumoniae in children with pneumonia.
resultsM. pneumoniae test was positive in 2188 (16.62%) out of 13161 pneumonia children. Children aged 5 - 9 years had the highest rate and summer was a season with high rate of M. pneumoniae incidence in Zhejiang province. During the course of study, in 526 pneumonia children with M. pneumoniae mono-infection and 30 healthy children cytokines assay was performed. IL-2 level of M. pneumoniae pneumonia children was lower than that of healthy children (median levels, pg/mL: IL-2: 3.2 vs. 5.7, P = 0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy children (median levels, pg/mL: IL-4: 3.2 vs. 1.5, P = 0.00; IL-10: 5.6 vs. 2.5, P = 0.001; IFN-γ: 20.4 vs. 4.8, P = 0.001).
conclusionsIL-2 decreases and IL-4, IL-10 and IFN-γ increase in children with M. pneumoniae pneumonia, which has a promising prospect in diagnosis of this disease in clinical practice.
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