Evidence map›Paper›PMID 26848299›Full record

ReviewPrzeglad menopauzalny = Menopause review2015

Association between estrogen levels and temporomandibular disorders: a systematic literature review.

Marcin Berger, Leszek Szalewski, Magdalena Bakalczuk, Grzegorz Bakalczuk, Szymon Bakalczuk, Jacek Szkutnik

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Przeglad menopauzalny = Menopause review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  10. Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcin BergerDepartment of Functional Masticatory Disorders, Medical University of Lublin, Lublin, Poland.
Leszek SzalewskiDepartment of Prosthetic Dentistry, Medical University of Lublin, Lublin, Poland.
Magdalena BakalczukDepartment of Functional Masticatory Disorders, Medical University of Lublin, Lublin, Poland.
Grzegorz BakalczukDepartment of Obstetrics, Gynaecology and Obstetrical-Gynaecological Nursing, Medical University of Lublin, Lublin, Poland.
Szymon BakalczukNon-Public Health Care Unit 'Ovum Reproduction and Andrology', Lublin, Poland.
Jacek SzkutnikDepartment of Functional Masticatory Disorders, Medical University of Lublin, Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo evaluate whether the hypothesis that estrogen levels are associated with temporomandibular disorders (TMD) in humans can be confirmed or contradicted by available literature. MATERIAL AND

methodsA systematic review based on the content of PubMed, Scopus, and Cochrane Library databases was performed. Studies were identified using a combination of key words 'temporomandibular disorder' and 'estrogen'. Nine studies were included into our review.

resultsThe relationship between estrogen levels and TMD was found in seven out of nine reviewed papers. Results from two papers suggest that a high estrogen level is associated with an increased prevalence of TMD. Five additional papers found a relationship between a low estrogen level and an increase in TMD pain. In considering the value of evidence and inconsistencies of results in the reviewed publications, we state that there is weak evidence to support the hypothesis that estrogen levels are associated with TMD.

conclusionsResults of reviewed studies were divergent and sometimes contradictory. One possible explanation is that estrogen influences TMD pain processing differently than temporomandibular joints (TMJ) structures, as shown in many animal studies. Estrogen may influence TMD pain processing differently than TMJ structures. We suggest consideration of the dual action of estrogen when planning future studies on its association with TMD.

Indexed as

estrogen levelhormone replacement therapymenopausetemporomandibular disorders

Identifiers

PMID26848299
PMCPMC4733902

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.