ArticleMetabolomics : Official journal of the Metabolomic Society
GC-MS metabolic profiling of Cabernet Sauvignon and Merlot cultivars during grapevine berry development and network analysis reveals a stage- and cultivar-dependent connectivity of primary metabolites.
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23 citing papers in PubMed, 71 citations in OpenAlex.
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- The chromosome-level genome foriScience · 2022Article
- Grafting with rootstocks promotes phenolic compound accumulation in grape berry skin during development based on integrative multi-omics analysis.Horticulture research · 2022Article
- Transcriptomic and metabolomic integration as a resource in grapevine to study fruit metabolite quality traits.Frontiers in plant science · 2022Article
- Multi-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season.GigaScience · 2021Article
- Workflow to Investigate Subtle Differences in Wine Volatile Metabolome Induced by Different Root Systems and Irrigation Regimes.Molecules (Basel, Switzerland) · 2021Article
- Adjustment of KInternational journal of molecular sciences · 2021Review
- Comparative Metabolic Profiling of Grape Pulp during the Growth Process Reveals Systematic Influences under Root Restriction.Metabolites · 2021Article
- Succession of Fungal Communities at Different Developmental Stages of Cabernet Sauvignon Grapes From an Organic Vineyard in Xinjiang.Frontiers in microbiology · 2021Article
- LC-MS/MS and GC-MS profiling as well as the antimicrobial effect of leaves of selected Yucca species introduced to Egypt.Scientific reports · 2020Article
- A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy.Metabolic brain disease · 2020Article
- UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols inBiomolecules · 2020Article
- Comparative Metabolic Profiling of Grape Skin Tissue along Grapevine Berry Developmental Stages Reveals Systematic Influences of Root Restriction on Skin Metabolome.International journal of molecular sciences · 2019Article
- Combined network analysis and machine learning allows the prediction of metabolic pathways from tomato metabolomics data.Communications biology · 2019Article
- Effect of elicitors on the metabolites in the suspension cell culture ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Genetic diversity of strawberry germplasm using metabolomic biomarkers.Scientific reports · 2018Article
- MS-Based Analytical Techniques: Advances in Spray-Based Methods and EI-LC-MS Applications.Journal of analytical methods in chemistry · 2018Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information about the total chemical composition of primary metabolites during grape berry development is scarce, as are comparative studies trying to understand to what extent metabolite modifications differ between cultivars during ripening. Thus, correlating the metabolic profiles with the changes occurring in berry development and ripening processes is essential to progress in their comprehension as well in the development of new approaches to improve fruit attributes. Here, the developmental metabolic profiling analysis across six stages from flowering to fully mature berries of two cultivars, Cabernet Sauvignon and Merlot, is reported at metabolite level. Based on a gas chromatography-mass spectrometry untargeted approach, 115 metabolites were identified and relative quantified in both cultivars. Sugars and amino acids levels show an opposite behaviour in both cultivars undergoing a highly coordinated shift of metabolite associated to primary metabolism during the stages involved in growth, development and ripening of berries. The changes are characteristic for each stage, the most pronounced ones occuring at fruit setting and pre-Veraison. They are associated to a reduction of the levels of metabolites present in the earlier corresponding stage, revealing a required catabolic activity of primary metabolites for grape berry developmental process. Network analysis revealed that the network connectivity of primary metabolites is stage- and cultivar-dependent, suggesting differences in metabolism regulation between both cultivars as the maturity process progresses. Furthermore, network analysis may represent an appropriate method to display the association between primary metabolites during berry developmental processes among different grapevine cultivars and for identifying potential biologically relevant metabolites.
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