ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2016
A local renal renin-angiotensin system activation via renal uptake of prorenin and angiotensinogen in diabetic rats.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies.Current hypertension reports · 2024Review
- GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions.Biological research · 2024Article
- Collecting duct renin regulates potassium homeostasis in mice.Acta physiologica (Oxford, England) · 2023Article
- Sex differences in soluble prorenin receptor in patients with type 2 diabetes.Biology of sex differences · 2021Article
- Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy.Frontiers in physiology · 2021Review
- Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney?Current hypertension reports · 2020Review
- The (pro)renin receptor in health and disease.Nature reviews. Nephrology · 2019Review
- Antinatriuretic phenomena seen in children with acute pyelonephritis may be related to the activation of intrarenal RAAS.Medicine · 2018Article
- HMedical molecular morphology · 2018Article
- Functional changes in vascular reactivity to adenosine receptor activation in type I diabetic mice.European journal of pharmacology · 2018Article
- Angiotensinogen import in isolated proximal tubules: evidence for mitochondrial trafficking and uptake.American journal of physiology. Renal physiology · 2017Article
- Possible role for glomerular-derived angiotensinogen in nephrotic syndrome.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2016Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The mechanism of activation of local renal renin-angiotensin system (RAS) has not been clarified in diabetes mellitus (DM). We hypothesized that the local renal RAS will be activated via increased glomerular filtration and tubular uptake of prorenin and angiotensinogen in diabetic kidney with microalbuminuria. Streptozotocin (STZ)-induced DM and control rats were injected with human prorenin and subsequently with human angiotensinogen. Human prorenin uptake was increased in podocytes, proximal tubules, macula densa, and cortical collecting ducts of DM rats where prorenin receptor (PRR) was expressed. Co-immunoprecipitation of kidney homogenates in DM rats revealed binding of human prorenin to the PRR and to megalin. The renal uptake of human angiotensinogen was increased in DM rats at the same nephron sites as prorenin. Angiotensin-converting enzyme was increased in podocytes, but decreased in the proximal tubules in DM rats, which may have contributed to unchanged renal levels of angiotensin despite increased angiotensinogen. The systolic blood pressure increased more after the injection of 20 μg of angiotensinogen in DM rats than in controls, accompanied by an increased uptake of human angiotensinogen in the vascular endothelium. In conclusion, endocytic uptake of prorenin and angiotensinogen in the kidney and vasculature in DM rats was contributed to increased tissue RAS and their pressor response to angiotensinogen.
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