ArticleInternational journal of nanomedicine2016
Fullerene mediates proliferation and cardiomyogenic differentiation of adipose-derived stem cells via modulation of MAPK pathway and cardiac protein expression.
Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Fullerol-reinforced antioxidantive 3D-printed bredigite scaffold for accelerating bone healing.Materials today. Bio · 2024Article
- Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics.Advanced engineering materials · 2023Article
- Fullerene CCardiovascular toxicology · 2023Article
- Electrically conductive carbon-based (bio)-nanomaterials for cardiac tissue engineering.Bioengineering & translational medicine · 2023Review
- Dietary zero-dimensional fullerene supplementation improves the meat quality, lipid metabolism, muscle fiber characteristics, and antioxidative status in finishing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Pomegranate seed extract enhances the inhibitory effect of adipose-derived mesenchymal stem cells on breast cancer cell line in co-culture conditions.Research in pharmaceutical sciences · 2022Article
- Fullerol-hydrogel microfluidic spheres forBioactive materials · 2021Article
- The Phosphonate Derivative of CInternational journal of molecular sciences · 2021Article
- Carbon nanomaterials for cardiovascular theranostics: Promises and challenges.Bioactive materials · 2021Review
- Extrinsically Conductive Nanomaterials for Cardiac Tissue Engineering Applications.Micromachines · 2021Review
- Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering.Histology and histopathology · 2021Review
- Effects of Aqueous Dispersions of CInternational journal of molecular sciences · 2021Article
- Effects of Functionalized Fullerenes on ROS Homeostasis Determine Their Cytoprotective or Cytotoxic Properties.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Zero-dimensional fullerenes can modulate the biological behavior of a variety of cell lines. However, the effects and molecular mechanisms of proliferation and cardiomyogenic differentiation in brown adipose-derived stem cells (BADSCs) are still unclear. In this study, we report the initial biological effects of fullerene-C60 on BADSCs at different concentrations. Results suggest that fullerene-C60 has no cytotoxic effects on BADSCs even at a concentration of 100 μg/mL. Fullerene-C60 improves the MAPK expression level and stem cell survival, proliferation, and cardiomyogenesis. Further, we found that the fullerene-C60 modulates cardiomyogenic differentiation. Fullerene-C60 improves the expression of cardiomyocyte-specific proteins (cTnT and α-sarcomeric actinin). At elevated concentration, fullerene-C60 reduces the incidence of diminished spontaneous cardiac differentiation of BADSCs with time. At the genetic level, fullerene-C60 (5 μg/mL) also improves the expression of cTnT. In addition, fullerene-C60 promotes the formation of gap junction among cells. These findings have important implications for clinical application of fullerenes in the treatment of myocardial infarction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.