Evidence map›Paper›PMID 26848152›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2017

Anomalous origin of the coronary artery arising from the opposite sinus: prevalence and outcomes in patients undergoing coronary CTA.

Michael K Cheezum, Brian Ghoshhajra, Marcio S Bittencourt, Edward A Hulten, Ami Bhatt, Negareh Mousavi, Nishant R Shah, Anne Marie Valente, Frank J Rybicki, Michael Steigner and 9 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Guideline
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  9. Catheterization Techniques for Anomalous Aortic Origin of Coronary Arteries.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Review
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  17. An unusual cause of cardiac arrest in a young infant.BMC cardiovascular disorders · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Michael K CheezumDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brian GhoshhajraDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marcio S BittencourtDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Edward A HultenDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ami BhattDepartment of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Negareh MousaviDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nishant R ShahDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anne Marie ValenteDepartment of Medicine (Cardiovascular Division), Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
Frank J RybickiDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Michael SteignerDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jon HainerDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thomas MacGillivrayDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Udo HoffmannDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Suhny AbbaraDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Marcelo F Di CarliDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Doreen DeFaria YehDepartment of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Michael LandzbergDepartment of Medicine (Cardiovascular Division), Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
Richard LiberthsonDepartment of Medicine, Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ron BlanksteinDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA rblankstein@partners.org.
Harvard University · USBrigham and Women's Hospital · USMassachusetts General Hospital · USBoston Children's Hospital · USThe University of Texas Southwestern Medical Center · US

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

aimsThe impact of coronary computed tomographic angiography (CTA) on management of anomalous origin of the coronary artery arising from the opposite sinus (ACAOS) remains uncertain. We examined the prevalence, anatomical characterization, and outcomes of ACAOS patients undergoing CTA. METHODS AND

resultsAmong 5991 patients referred for CTA at two tertiary hospitals between January 2004 and June 2014, we identified 103 patients (1.7% prevalence) with 110 ACAOS vessels. Mean age was 52 years (range 5-83, 63% male), with 55% previously known ACAOS and 45% discovered on CTA. ACAOS subtypes included: 39% interarterial (n = 40 anomalous right coronary artery, n = 3 anomalous left coronary artery), 38% retroaortic, 15% subpulmonic, 5% prepulmonic, and 2% other. ACAOS patients were assessed for symptoms, ischaemic test results, revascularization, all-cause or cardiovascular (CV) death, and myocardial infarction. CTAs were reviewed for ACAOS course, take-off height and angle, length and severity of proximal narrowing, intramural course, and obstructive coronary artery disease (CAD). In follow-up (median 5.8 years), there were 20 surgical revascularizations and 3 CV deaths. After adjusting for obstructive CAD (n = 21/103, 20%), variables associated with ACAOS revascularization included the following: CV symptoms, proximal vessel narrowing ≥50%, length of narrowing >5.4 mm, and an interarterial course.

conclusionThe prevalence of ACAOS on CTA was 1.7%, including 45% of cases discovered incidentally. CTA provided excellent characterization of ACAOS features associated with coronary revascularization, including the length and severity of proximal vessel narrowing.

Indexed as

AdultAge FactorsCohort StudiesComputed Tomography AngiographyCoronary AngiographyCoronary Vessel AnomaliesFemaleFollow-Up StudiesHumansMaleMiddle AgedMultidetector Computed TomographyMyocardial IschemiaMyocardial RevascularizationRetrospective StudiesRisk Assessmentanomalous coronary arterycoronary computed tomographic angiographyprognosisrevascularizationsudden cardiac death

Identifiers

PMID26848152
PMCPMC6279103
OpenAlexW2254072991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.