ArticleThe journal of pain2016
Increasing Neuroplasticity to Bolster Chronic Pain Treatment: A Role for Intermittent Fasting and Glucose Administration?
Article in The journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02681081 (Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Does pain influence control of muscle force? A systematic review and meta-analysis.European journal of pain (London, England) · 2025Pooled it
- The Effectiveness of Intermittent Fasting, Time Restricted Feeding, Caloric Restriction, a Ketogenic Diet and the Mediterranean Diet as Part of the Treatment Plan to Improve Health and Chronic Musculoskeletal Pain: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Efficacy of Nutritional Strategies on the Improvement of the Performance and Health of the Athlete: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Dietary Patterns and Interventions to Alleviate Chronic Pain.Nutrients · 2020Pooled it
- Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial.Nutrients · 2021Trial
- Midkine-Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The relationship between abnormal glucose metabolism and chronic pain.Cell & bioscience · 2025Review
- Cannflavins isolated from Cannabis sativa impede Caenorhabditis elegans response to noxious heat.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Increased microglia activation in late non-central nervous system cancer survivors links to chronic systemic symptomatology.Human brain mapping · 2023Article
- Conscious connected breathing with breath retention intervention in adults with chronic low back pain: protocol for a randomized controlled pilot study.Pilot and feasibility studies · 2023Article
- Influence of acute fasting on pain tolerance in healthy subjects: a randomised crossover study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- The Health-Promoting Effects and the Mechanism of Intermittent Fasting.Journal of diabetes research · 2023Review
- Intermittent Fasting: Potential Utility in the Treatment of Chronic Pain across the Clinical Spectrum.Nutrients · 2022Review
- Review
- Feasibility and acceptability of time-restricted eating in a group of adults with multiple sclerosis.Frontiers in neurology · 2022Article
- Article
- Re-test reliability and internal consistency of EEG alpha-band oscillations in older adults with chronic knee pain.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Differential regulation of the immune system in a brain-liver-fats organ network during short-term fasting.Molecular metabolism · 2020Article
- The analgesic effect of refeeding on acute and chronic inflammatory pain.Scientific reports · 2019Article
- Chronic multisite pain: evaluation of a new geriatric syndrome.Aging clinical and experimental research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledNeuroplastic changes in brain structure and function are not only a consequence of chronic pain but are involved in the maintenance of pain symptoms. Thus, promotion of adaptive, treatment-responsive neuroplasticity represents a promising clinical target. Emerging evidence about the human brain's response to an array of behavioral and environmental interventions may assist in identifying targets to facilitate increased neurobiological receptivity, promoting healthy neuroplastic changes. Specifically, strategies to maximize neuroplastic responsiveness to chronic pain treatment could enhance treatment gains by optimization of learning and positive central nervous system adaptation. Periods of heightened plasticity have been traditionally identified with the early years of development. More recent research, however, has identified a wide spectrum of methods that can be used to "reopen" and enhance plasticity and learning in adults. In addition to transcranial direct current stimulation and transcranial magnetic stimulation, behavioral and pharmacological interventions have been investigated. Intermittent fasting and glucose administration are two propitious strategies, that are noninvasive, inexpensive to administer, implementable in numerous settings, and might be applicable across differing chronic pain treatments. Key findings and neurophysiological mechanisms are summarized, and evidence for the potential clinical contributions of these two strategies toward ameliorating chronic pain is presented. PERSPECTIVE: Neuroplastic changes are a defining feature of chronic pain and a complicating factor in treatment. Noninvasive strategies to optimize the brain's response to treatment interventions might improve learning and memory, increase the positive adaptability of the central nervous system, and enhance treatment outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.