Evidence map›Paper›PMID 26847728›Full record

Trial reportPhysiological reports2016

Glucose-loading reduces bone remodeling in women and osteoblast function in vitro.

Itamar Levinger, Ego Seeman, George Jerums, Glenn K McConell, Mark S Rybchyn, Samantha Cassar, Elizabeth Byrnes, Steve Selig, Rebecca S Mason, Peter R Ebeling and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Acute continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, attenuates postprandial suppression of circulating osteocalcin in young overweight and obese adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
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  13. The Effect of Type 2 Diabetes on Bone Biomechanics.Current osteoporosis reports · 2019
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  17. Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Itamar LevingerClinical Exercise Science Program, Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia itamar.levinger@vu.edu.au.
Ego SeemanDepartment of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia.
George JerumsDepartment of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia.
Glenn K McConellClinical Exercise Science Program, Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia College of Health and Biomedicine, Victoria University, Melbourne, Australia.
Mark S RybchynDepartment of Physiology, Bosch Institute for Medical Research, University of Sydney, Sydney, Australia.
Samantha CassarClinical Exercise Science Program, Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Australia.
Elizabeth ByrnesPathWest QEII Medical Centre, Perth, Australia.
Steve SeligSchool of Exercise & Nutrition Sciences, Deakin University, Melbourne, Australia.
Rebecca S MasonDepartment of Physiology, Bosch Institute for Medical Research, University of Sydney, Sydney, Australia.
Peter R EbelingDepartment of Medicine, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
Tara C Brennan-SperanzaDepartment of Physiology, Bosch Institute for Medical Research, University of Sydney, Sydney, Australia.
University of Sydney · AUVictoria University · AUUniversity of Melbourne · AUDeakin University · AUMonash University · AUQueen Elizabeth II Medical Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with a reduction in osteoblast life span and the volume of bone formed by each basic multicellular unit. Each time bone is resorbed, less is deposited producing microstructural deterioration. Aging is also associated with insulin resistance and hyperglycemia, either of which may cause, or be the result of, a decline in undercarboxylated osteocalcin (ucOC), a protein produced by osteoblasts that increases insulin sensitivity. We examined whether glucose-loading reduces bone remodeling and ucOC in vivo and osteoblast function in vitro, and so compromises bone formation. We administered an oral glucose tolerance test (OGTT) to 18 pre and postmenopausal, nondiabetic women at rest and following exercise and measured serum levels of bone remodeling markers (BRMs) and ucOC. We also assessed whether increasing glucose concentrations with or without insulin reduced survival and activity of cultured human osteoblasts. Glucose-loading at rest and following exercise reduced BRMs in pre and postmenopausal women and reduced ucOC in postmenopausal women. Higher glucose correlated negatively, whereas insulin correlated positively, with baseline BRMs and ucOC. The increase in serum glucose following resting OGTT was associated with the reduction in bone formation markers. D-glucose (>10 mmol L(-1)) increased osteoblast apoptosis, reduced cell activity and osteocalcin expression compared with 5 mmol L(-1). Insulin had a protective effect on these parameters. Collagen expression in vitro was not affected in this time course. In conclusion, glucose exposure reduces BRMs in women and exercise failed to attenuate this suppression effect. The suppressive effect of glucose on BRMs may be due to impaired osteoblast work and longevity. Whether glucose influences material composition and microstructure remains to be determined.

Indexed as

AdultAgingBlood GlucoseBone RemodelingCells, CulturedCross-Over StudiesExerciseFemaleGlucoseGlucose Tolerance TestHumansImmunoassayInsulinMiddle AgedOsteoblastsOsteocalcinBlood GlucoseGlucoseInsulinOsteocalcinBone remodelingexerciseglycemic controlin vitroin vivoosteoblasts function

Identifiers

PMID26847728
PMCPMC4758933
OpenAlexW2300784889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.