ArticleNeuroradiology2016
fMRI activation in the middle frontal gyrus as an indicator of hemispheric dominance for language in brain tumor patients: a comparison with Broca's area.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
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- Altered brain activity in the bilateral frontal cortices and neural correlation with cognitive impairment in schizophrenia.Brain imaging and behavior · 2022Article
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- rsfMRI based evidence for functional connectivity alterations in adults with developmental stuttering.Heliyon · 2021Article
- Early prediction of putamen imaging features in HIV-associated neurocognitive impairment syndrome.BMC neurology · 2021Article
- Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand.BMC neurology · 2021Article
- Functional MRI study of language organization in left-handed and right-handed trilingual subjects.Scientific reports · 2020Article
- Changes in Cortical Thickness Are Associated With Cognitive Ability in Postoperative School-Aged Children With Tetralogy of Fallot.Frontiers in neurology · 2020Article
- Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study.Neuropsychiatric disease and treatment · 2020Article
- Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors.AJNR. American journal of neuroradiology · 2019Article
- Paradoxical Activation in the Cerebellum During Language fMRI in Patients with Brain Tumors: Possible Explanations Based on Neurovascular Uncoupling and Functional Reorganization.Cerebellum (London, England) · 2018Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
introductionFunctional MRI (fMRI) can assess language lateralization in brain tumor patients; however, this can be limited if the primary language area-Broca's area (BA)-is affected by the tumor. We hypothesized that the middle frontal gyrus (MFG) can be used as a clinical indicator of hemispheric dominance for language during presurgical workup.
methodsFifty-two right-handed subjects with solitary left-hemispheric primary brain tumors were retrospectively studied. Subjects performed a verbal fluency task during fMRI. The MFG was compared to BA for fMRI voxel activation, language laterality index (LI), and the effect of tumor grade on the LI.
resultsLanguage fMRI (verbal fluency) activated more voxels in MFG than in BA (MFG = 315, BA = 216, p < 0.001). Voxel activations in the left-hemispheric MFG and BA were positively correlated (r = 0.69, p < 0.001). Mean LI in the MFG was comparable to that in BA (MFG = 0.48, BA = 0.39, p = 0.06). LIs in MFG and BA were positively correlated (r = 0.62, p < 0.001). Subjects with high-grade tumors demonstrate lower language lateralization than those with low-grade tumors in both BA and MFG (p = 0.02, p = 0.02, respectively).
conclusionMFG is comparable to BA in its ability to indicate hemispheric dominance for language using a measure of verbal fluency and may be an adjunct measure in the clinical determination of language laterality for presurgical planning.
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