Evidence map›Paper›PMID 26847647›Full record

ReviewCardiovascular drugs and therapy2016

Experimental Biology for the Identification of Causal Pathways in Atherosclerosis.

Yanhong Guo, Minerva T Garcia-Barrio, Laiyuan Wang, Y Eugene Chen

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular drugs and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. The Impact of Single Nucleotide Polymorphisms and Other Mechanisms on Aspirin Resistance.Cardiovascular & hematological disorders drug targets · 2025
    Review
  2. Association of Common Variants ofInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yanhong GuoCardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA.
Minerva T Garcia-BarrioCardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Laiyuan WangCardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA.
Y Eugene ChenCardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA. echenum@umich.edu.
University of Michigan–Ann Arbor · USMorehouse School of Medicine · US

Funding

The Role of PPAR-gamma in Vascular Lesion FormationR01HL068878 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2002 to 2019
$7.6M
Morehouse Cardiovascular Research Center of ExcellenceP50HL117929 · NHLBI · MOREHOUSE SCHOOL OF MEDICINE · PI TAYLOR, HERMAN ALFRED · 2013 to 2018
$6.7M
MPO, HDL Dysfunction and Cardiovascular DiseaseR01HL129778 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2015 to 2018
$2.9M
CETP and HDL Function in Cardiovascular DiseasesR01HL117491 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2013 to 2016
$2.4M
NHLBI NIH HHS HL068878NHLBI NIH HHS HL117491NHLBI NIH HHS HL129778NHLBI NIH HHS P50 HL117929NHLBI NIH HHS P50-HL117929NHLBI NIH HHS R01 HL068878NHLBI NIH HHS R01 HL117491NHLBI NIH HHS R01 HL129778
6 · The paper itself

Abstract

More than 60 genomic loci have been implicated by genome-wide association studies (GWAS) and exome-wide association studies as conferring an increased risk of myocardial infarction and coronary artery disease (CAD). However, the causal gene and variant is often unclear. Using the functional analysis of genetic variants in experimental animal models, we anticipate understanding which candidate gene at a specific locus is associated with atherosclerosis and revealing the underlying molecular and cellular mechanisms, ultimately leading to the identification of causal pathways in atherosclerosis and may provide novel therapeutic targets for the treatment of atherosclerotic cardiovascular disease.

Indexed as

AnimalsAtherosclerosisDisease Models, AnimalGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansRisk FactorsArteriosclerosisCardiovascular diseasesGenome-wide association studiesInflammationLipidsMetabolism

Identifiers

PMID26847647
PMCPMC7088260
OpenAlexW2267495081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.