ArticleJournal of biomolecular NMR2016
Non-uniform sampling of NMR relaxation data.
Article in Journal of biomolecular NMR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes.Journal of biomolecular NMR · 2023Article
- nus-tool: A unified program for generating and analyzing sample schedules for nonuniformly sampled NMR experiments.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023Article
- Enhanced Nuclear Magnetic Resonance Spectroscopy with Isotropic Mixing as a Pseudodimension.Analytical chemistry · 2022Article
- Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins.STAR protocols · 2021Article
- A simple approach for reconstruction of non-uniformly sampled pseudo-3D NMR data for accurate measurement of spin relaxation parameters.Journal of biomolecular NMR · 2021Article
- Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampledMagnetic resonance (Gottingen, Germany) · 2021Article
- Boosting the resolution of low-fieldJournal of biomolecular NMR · 2020Article
- The influence of the probability density function on spectral quality in nonuniformly sampled multidimensional NMR.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Accelerating 2D NMR relaxation dispersion experiments using iterated maps.Journal of biomolecular NMR · 2019Article
- Using Deep Neural Networks to Reconstruct Non-uniformly Sampled NMR Spectra.Journal of biomolecular NMR · 2019Article
- Reaching the sparse-sampling limit for reconstructing a single peak in a 2D NMR spectrum using iterated maps.Journal of biomolecular NMR · 2019Article
- Article
- Characterization of Internal Protein Dynamics and Conformational Entropy by NMR Relaxation.Methods in enzymology · 2019Article
- Assigning methyl resonances for protein solution-state NMR studies.Methods (San Diego, Calif.) · 2018Article
- Measurement of protein backboneJournal of biomolecular NMR · 2017Article
- Joint non-uniform sampling of all incremented time delays for quicker acquisition in protein relaxation studies.Journal of biomolecular NMR · 2017Article
- Pitfalls in compressed sensing reconstruction and how to avoid them.Journal of biomolecular NMR · 2017Article
- Accurate determination of rates from non-uniformly sampled relaxation data.Journal of biomolecular NMR · 2016Article
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2 authors.
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Abstract
The use of non-uniform sampling of NMR spectra may give significant reductions in the data acquisition time. For quantitative experiments such as the measurement of spin relaxation rates, non-uniform sampling is however not widely used as inaccuracies in peak intensities may lead to errors in the extracted dynamic parameters. By systematic reducing the coverage of the Nyquist grid of (15)N Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion datasets for four different proteins and performing a full data analysis of the resulting non-uniform sampled datasets, we have compared the performance of the multi-dimensional decomposition and iterative re-weighted least-squares algorithms in reconstructing spectra with accurate peak intensities. As long as a single fully sampled spectrum is included in a series of otherwise non-uniform sampled two-dimensional spectra, multi-dimensional decomposition reconstructs the non-uniform sampled spectra with high accuracy. For two of the four analyzed datasets, a coverage of only 20% results in essentially the same results as the fully sampled data. As exemplified by other data, such a low coverage is in general not enough to produce reliable results. We find that a coverage level not compromising the final results can be estimated by recording a single full two-dimensional spectrum and reducing the spectrum quality in silico.
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