Evidence map›Paper›PMID 26847416›Full record

ArticleNutrition and cancer2016

Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study.

Terrence M Vance, Ying Wang, L Joseph Su, Elizabeth T H Fontham, Susan E Steck, Lenore Arab, Jeannette T Bensen, James L Mohler, Ming-Hui Chen, Ock K Chun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition and cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Terrence M Vancea Department of Nutritional Sciences , University of Connecticut , Storrs , Connecticut , USA.
Ying Wanga Department of Nutritional Sciences , University of Connecticut , Storrs , Connecticut , USA.
L Joseph Sub Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute , Bethesda , Maryland , USA.
Elizabeth T H Fonthamc School of Public Health, Louisiana State University Health Sciences Center , New Orleans , Louisiana , USA.
Susan E Steckd Department of Epidemiology and Biostatistics , Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.
Lenore Arabe David Geffen School of Medicine, University of California, Los Angeles , Los Angeles , California , USA.
Jeannette T Bensenf University of North Carolina at Chapel Hill, School of Public Health , Chapel Hill , North Carolina , USA.
James L Mohlerf University of North Carolina at Chapel Hill, School of Public Health , Chapel Hill , North Carolina , USA.
Ming-Hui Chenh Department of Statistics , University of Connecticut , Storrs , Connecticut , USA.
Ock K Chuna Department of Nutritional Sciences , University of Connecticut , Storrs , Connecticut , USA.
University of Connecticut · USUniversity of North Carolina at Chapel Hill · USLouisiana State University Health Sciences Center New Orleans · USNational Cancer Institute · USUniversity of California, Los Angeles · USUniversity of South Carolina · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Does Dietary Antioxidant Predict Aggressiveness of Prostate Cancer?R03CA159421 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI CHUN, OCK K. · 2012 to 2013
$155k
NCI NIH HHS 1R03CA159421-01A1NCI NIH HHS P30 CA016086NCI NIH HHS R03 CA159421
6 · The paper itself

Abstract

The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Cases were classified as either high aggressive, low aggressive, or intermediate aggressive. TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 antioxidants measured via food frequency questionnaire. EA reported greater dietary TAC from diet and supplements combined (P < 0.0001). In both minimally and fully adjusted logistic regression models, TAC from diet and supplements combined was associated with a reduced odds of high aggressive prostate cancer in all men, AA and EA: odds ratios for highest vs. lowest level (>1500 vs. <500 mg vitamin C equivalent/day): 0.31 [95% confidence interval (CI): 0.15, 0.67; P-trend < 0.01], 0.28 (95% CI: 0.08, 0.96; P-trend < 0.001), and 0.36 (95% CI: 0.15, 0.86; P-trend = 0.58), respectively. These associations did not appear to differ between AA and EA. These data suggest that greater intake of antioxidants is associated with less aggressive prostate cancer. Additional research is needed to confirm these results and determine the underlying mechanisms.

Indexed as

AdultAgedAntioxidantsAscorbic AcidBlack or African AmericanDietary SupplementsFeeding BehaviorHumansLogistic ModelsLouisianaMaleMiddle AgedNorth CarolinaProstatic NeoplasmsSocioeconomic FactorsWhite PeopleAntioxidantsAscorbic Acid

Identifiers

PMID26847416
PMCPMC4821782
OpenAlexW2278775045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.