ArticleObesity (Silver Spring, Md.)2016
Reprogramming of defended body weight after Roux-En-Y gastric bypass surgery in diet-induced obese mice.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Weight loss in adult male Wistar rats by Roux-en-Y gastric bypass is primarily explained by caloric intake reduction and presurgery body weight.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium.The American journal of clinical nutrition · 2023Article
- Impact of preoperative weight loss achieved by gastric balloon on peri- and postoperative outcomes of bariatric surgery in super-obese patients: a retrospective matched-pair analysis.Langenbeck's archives of surgery · 2022Article
- Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application.Molecular metabolism · 2021Review
- Mechanism of insulin resistance in obesity: a role of ATP.Frontiers of medicine · 2021Review
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice.PloS one · 2020Article
- Surgical Mouse Models of Vertical Sleeve Gastrectomy and Roux-en Y Gastric Bypass: a Review.Obesity surgery · 2019Review
- Recent advances in understanding body weight homeostasis in humans.F1000Research · 2018Review
- Pharmacotherapy for Patients with Obesity.Clinical chemistry · 2018Review
- Obesity Pathogenesis: An Endocrine Society Scientific Statement.Endocrine reviews · 2017Review
- Hyperinsulinemia: a Cause of Obesity?Current obesity reports · 2017Review
- Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis.Current opinion in pharmacology · 2016Review
- Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity.Molecular metabolism · 2016Article
- Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice.Molecular metabolism · 2016Article
- Persistent metabolic adaptation 6 years after "The Biggest Loser" competition.Obesity (Silver Spring, Md.) · 2016Article
- Suppressed Fat Appetite after Roux-en-Y Gastric Bypass Surgery Associates with Reduced Brain μ-opioid Receptor Availability in Diet-Induced Obese Male Rats.Frontiers in neuroscience · 2016Article
- The Use of Rat and Mouse Models in Bariatric Surgery Experiments.Frontiers in nutrition · 2016Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveRoux-en-Y gastric bypass surgery (RYGB) results in sustained lowering of body weight in most patients, but the mechanisms involved are poorly understood. The aim of this study was to obtain support for the notion that reprogramming of defended body weight, rather than passive restriction of energy intake, is a fundamental mechanism of RYGB.
methodsMale C57BL6J mice reaching different degrees of obesity on a high-fat diet either with ad libitum access or with caloric restriction (weight-reduced) were subjected to RYGB.
resultsRYGB-induced weight loss and fat mass loss were proportional to pre-surgical levels, with moderately obese mice losing less body weight and fat compared with very obese mice. Remarkably, mice that were weight-reduced to the level of chow controls before surgery immediately gained weight after surgery, exclusively accounted for by lean mass gain.
conclusionsThe results provide additional evidence for reprogramming of a new defended body weight as an important principle by which RYGB lastingly suppresses body weight. RYGB appears to selectively abolish defense of a higher fat mass level, while remaining sensitive to the defense of lean mass. The molecular and physiological mechanisms underlying this reprogramming remain to be elucidated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.