ReviewCurrent topics in microbiology and immunology2016
Histophilosis as a Natural Disease.
Review in Current topics in microbiology and immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Microbial Landscape of Bull (Animals : an open access journal from MDPI · 2026Article
- Novel Recombinase Polymerase Amplification Assay Is Sensitive for Detection of Macrolide Resistance Genes Relevant to Bovine Respiratory Disease Management in Feedlot Calves.Veterinary sciences · 2025Article
- Characterization of proteins present in the biofilm matrix and outer membrane vesicles ofmBio · 2025Article
- Contribution of Hfq to gene regulation and virulence inInfection and immunity · 2024Article
- Article
- An overview of the detection of bovine respiratory disease complex pathogens using immunohistochemistry: emerging trends and opportunities.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Review
- A Comprehensive Review of the Common Bacterial Infections in Dairy Calves and Advanced Strategies for Health Management.Veterinary medicine (Auckland, N.Z.) · 2024Review
- Temporal changes in ewe vaginal microbiota throughout gestation.Frontiers in microbiology · 2024Article
- Association between respiratory disease pathogens in calves near feedlot arrival with treatment for bovine respiratory disease and subsequent antimicrobial resistance status.Frontiers in veterinary science · 2024Article
- Neglected bacterial infections associated to bovine respiratory disease in lactating cows from high-yielding dairy cattle herds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Clinical-pathological findings induced by Histophilus somni isolated in subacute cardiac death in feedlot cattle.Veterinary research communications · 2023Article
- Histophilus somni disease conditions with simultaneous infections by ovine gammaherpesvirus 2 in cattle herds from Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Antimicrobial resistance and associated genetic background ofFrontiers in veterinary science · 2022Article
- Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves.The Journal of veterinary medical science · 2021Article
- Ewe Vaginal Microbiota: Associations With Pregnancy Outcome and Changes During Gestation.Frontiers in microbiology · 2021Article
- Polymicrobial Biofilm Interaction BetweenFrontiers in microbiology · 2020Article
- Identification of Histophilus somni by a nanomaterial optical fiber biosensor assay.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- A Predominant Clonal Thromboembolic Meningoencephalitis Group ofFrontiers in veterinary science · 2018Article
- Integrative Conjugative Element ICEFrontiers in veterinary science · 2018Article
- Evolving views on bovine respiratory disease: An appraisal of selected key pathogens - Part 1.Veterinary journal (London, England : 1997) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histophilus somni is responsible for sporadic disease worldwide in cattle and, to a lesser extent, in small ruminants, bighorn sheep (Ovis canadensis), and North American bison (Bison bison). The importance of H. somni diseases can be attributed to improved clinical and laboratory recognition, combined with the growth in intensive management practices for cattle. Although outbreaks of bovine histophilosis can occur year-round, in northern and southern hemispheres, it is most frequent in late fall and early winter. Weather, stress, dietary changes, and comingling of cattle are likely to be major triggers for outbreaks. The most frequent clinical expressions of histophilosis include undifferentiated fever, fibrinosuppurative pneumonia, encephalitis-leptomeningitis, necrotizing myocarditis, and diffuse pleuritis. Neurological disease occurs either as thrombotic meningoencephalitis (TME) or as suppurative meningitis with ventriculitis. Acute myocarditis is characteristically necrotizing and generally involves one or both papillary muscles in the left ventricular myocardium. Biofilm-like aggregates of bacteria occur in capillaries and veins in myocardium, in the central nervous system, and on endocardial surfaces. H. somni is a component of bovine respiratory disease (BRD) complex. In our experience, it is most commonly diagnosed in subacute-to-chronic polymicrobial pulmonary infections in combination with Mannheimia haemolytica, Trueperella pyogenes, Pasteurella multocida, or Mycoplasma bovis. Other, less common forms of H. somni disease present as polyarthritis/tenosynovitis, abortion with placentitis and fetal septicemia, epididymitis-orchitis, and ocular infections. It is likely that H. somni is under-recognized clinically and diagnostically. Most state and provincial laboratories in North America rely on bacterial isolation to confirm infection. The use of more sensitive detection methods on field cases of histophilosis will help resolve the pathogenesis of H. somni in natural outbreaks, and whether the disease is as common elsewhere as it is in Canada.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.