Evidence map›Paper›PMID 26847311›Full record

ArticleYonsei medical journal2016

Non-Paraneoplastic Autoimmune Retinopathy: The First Case Report in Korea.

Eun Young Choi, Min Kim, Grazyna Adamus, Hyoung Jun Koh, Sung Chul Lee

Open access · goldAbstract readCase Reports
In one paragraph

Article in Yonsei medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Detection of serum anti-retinal antibodies in the Chinese patients with presumed autoimmune retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  6. Article
  7. Autoimmune retinopathy: A Review.International journal of retina and vitreous · 2018
    Review
  8. Review
  9. Antiretinal antibody- proven autoimmune retinopathy.Indian journal of ophthalmology · 2017
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Eun Young ChoiDepartment of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Min KimDepartment of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. minkim76@hotmail.com.
Grazyna AdamusOcular Immunology Laboratory, Casey Eye Institute-BRB, Oregon Health & Science University, Portland, OR, USA.
Hyoung Jun KohThe Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Sung Chul LeeThe Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Gangnam Severance Hospital · KRSeverance Hospital · KROregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune retinopathy (AIR) is an immune-mediated retinopathy, resulting from an immunologic process caused by the aberrant recognition of retinal antigens as autoantigens. The diagnosis of AIR involves the detection of antiretinal antibodies with concurrent clinical and electrophysiological evidence of retinopathy. A 40-year-old patient presented with progressive loss of bilateral vision over several months. A fundus examination was unremarkable. Spectral domain optical coherence tomography revealed a blurred photoreceptor ellipsoid zone at the subfoveal region in both eyes with more prominent disruption in the left eye. Full-field electroretinography (ERG) showed relatively normal rod and cone responses in the right eye, and decreased photopic bwaves with minimal attenuation of a-waves in the left eye. Multifocal ERG demonstrated slightly reduced amplitude of the inner segment ring in the right eye and decreased amplitudes and delayed latencies of all modalities in the left eye. The patient was suspected to have AIR and it was supported by positive Western blots for 23-kDa protein, enolase (46-kDa), aldolase (40-kDa), 62-kDa and 78-kDa proteins and by immunohistochemical staining of human retinal bipolar and ganglion cells. Despite the immunosuppressive treatment, the destruction of the retinal photoreceptors progressed, and immunosuppressive interventions produced very little visual improvement. We report on what is, to the best of our knowledge, the very first case of serologically confirmed nonparaneoplastic AIR in Korea.

Indexed as

AutoantibodiesAutoantigensAutoimmune DiseasesElectroretinographyHumansImmunologic FactorsParaneoplastic SyndromesParaneoplastic Syndromes, OcularPhosphopyruvate HydrataseRecoverinRepublic of KoreaRetinaRetinal DiseasesTomography, Optical CoherenceAutoantibodiesAutoantigensImmunologic FactorsPhosphopyruvate HydrataseRecoverinAIRantiretinal antibodiesAutoimmune retinopathyenolasenonparaneoplastic autoimmune retinopathyrecoverin

Identifiers

PMID26847311
PMCPMC4740551
OpenAlexW2266702911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.