ArticleBritish journal of haematology2016
Predictors of early death and survival among children, adolescents and young adults with acute myeloid leukaemia in California, 1988-2011: a population-based study.
Article in British journal of haematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Comparable on-therapy mortality and supportive care requirements in Black and White patients following initial induction for pediatric acute myeloid leukemia.Pediatric blood & cancer · 2019Trial
- Disparities in Rural-Urban Cancer Care Outcomes among Pediatric, Adolescent, and Young Adult Populations: A Comprehensive Narrative Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Review
- Race and Ethnicity and Overall Survival in Pediatric Acute Myeloid Leukemia.JAMA network open · 2026Article
- Real-world generalizability of clinical trial cytomolecular risk in pediatric acute myeloid leukemia: a report from the REAL-AML cohort.Journal of the National Cancer Institute · 2026Article
- Impact of neighborhood archetypes on overall mortality among young patients with acute leukemia in California.Cancer · 2025Article
- Travel-time barriers to specialized cancer care for adolescents and young adults with acute lymphoblastic leukemia.JNCI cancer spectrum · 2024Article
- Survival Trends Among Adolescents and Young Adults Diagnosed With Cancer in the United States: Comparisons With Children and Older Adults.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- Ethnic disparities in childhood leukemia survival by border residence: A Texas population-based analysis.Cancer · 2023Article
- Risk of early death in adolescents and young adults with cancer: a population-based study.Journal of the National Cancer Institute · 2023Article
- Increased survival disparities among children and adolescents & young adults with acute myeloid leukemia: A Dutch population-based study.International journal of cancer · 2022Article
- Fluid overload is associated with increased 90-day mortality in AML patients undergoing induction chemotherapy.Annals of hematology · 2021Article
- Impact of fluid overload and infection on respiratory adverse event development during induction therapy for childhood acute myeloid leukemia.Pediatric blood & cancer · 2019Article
- Disparities in Survival and Health Outcomes in Childhood Leukemia.Current hematologic malignancy reports · 2019Review
- Early mortality after diagnosis of cancer of the head and neck - A population-based nationwide study.PloS one · 2019Article
- Patterns of unmet needs in adolescent and young adult (AYA) cancer survivors: in their own words.Journal of cancer survivorship : research and practice · 2017Article
- Complications preceding early deaths in Black and White children with acute myeloid leukemia.Pediatric blood & cancer · 2017Article
- Cancer survival in Qidong between 1972 and 2011: A population-based analysis.Molecular and clinical oncology · 2017Article
- Evaluation of the safety and efficacy of recombinant soluble thrombomodulin for patients with disseminated intravascular coagulation associated with acute leukemia: multicenter prospective study by the Tohoku Hematology Forum.International journal of hematology · 2017Article
- The role of acuity of illness at presentation in early mortality in black children with acute myeloid leukemia.American journal of hematology · 2017Article
- Association of Early Chemotherapy With Reduced In-Hospital Mortality and Complications in Acute Promyelocytic Leukemia: Insights From a Nationwide Cohort.Cancer diagnosis & prognosisArticle
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8 authors.
Funding
Abstract
A better understanding of factors associated with early death and survival among children, adolescents and young adults with acute myeloid leukaemia (AML) may guide health policy aimed at improving outcomes in these patients. We examined trends in early death and survival among 3935 patients aged 0-39 years with de novo AML in California during 1988-2011 and investigated the associations between sociodemographic and selected clinical factors and outcomes. Early death declined from 9·7% in 1988-1995 to 7·1% in 2004-2011 (P = 0·062), and survival improved substantially over time. However, 5-year survival was still only 50% (95% confidence interval 47-53%) even in the most recent treatment period (2004-2011). Overall, the main factors associated with poor outcomes were older age at diagnosis, treatment at hospitals not affiliated with National Cancer Institute-designated cancer centres, and black race/ethnicity. For patients diagnosed during 1996-2011, survival was lower among those who lacked health insurance compared to those with public or private insurance. We conclude that mortality after AML remained strikingly high in California and increased with age. Possible strategies to improve outcomes include wider insurance coverage and treatment at specialized cancer centres.
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