Evidence map›Paper›PMID 26847015›Full record

ReviewPhysical therapy2016

Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships.

Heather H Ross, Fabrisia Ambrosio, Randy D Trumbower, Paul J Reier, Andrea L Behrman, Steven L Wolf

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physical therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bioscaffold-Induced Brain Tissue Regeneration.Frontiers in neuroscience · 2019
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heather H RossH.H. Ross, MPT, PhD, Department of Physical Therapy, College of Public Health Sciences, Brenau University, 500 Washington St SE, Gainesville, GA 30501 (USA). hross@brenau.edu.
Fabrisia AmbrosioF. Ambrosio, MPT, PhD, Departments of Physical Medicine & Rehabilitation, Physical Therapy, Orthopaedic Surgery, and Microbiology & Molecular Genetics and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Randy D TrumbowerR.D. Trumbower, MPT, PhD, Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, Georgia.
Paul J ReierP.J. Reier, PhD, Department of Neuroscience, University of Florida, Gainesville, Florida.
Andrea L BehrmanA.L. Behrman, PT, PhD, FAPTA, Department of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky.
Steven L WolfS.L. Wolf, PT, PhD, FAPTA, Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine; Department of Cell Biology, Emory University School of Medicine; and Center of Excellence in Vision and Neurocognitive Rehabilitation, Atlanta, Georgia.

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
MULTICENTER CAREER DEVELOPMENT PROGRAM FOR PHYSICAL AND OCCUPATIONAL THERAPYK12HD055931 · NICHD · WASHINGTON UNIVERSITY · PI HAYES, MARCIE HARRIS · 2007 to 2021
$12.7M
Mechanisms of intermittent hypoxia-induced motor recovery in persons with SCIR01HD081274 · NICHD · SPAULDING REHABILITATION HOSPITAL · PI TRUMBOWER, RANDY D · 2014 to 2018
$2.4M
NIA NIH HHS P30 AG024827NICHD NIH HHS K12 HD055931NICHD NIH HHS R01 HD081274
6 · The paper itself

Abstract

The goal of regenerative medicine is to restore function through therapy at levels such as the gene, cell, tissue, or organ. For many disorders, however, regenerative medicine approaches in isolation may not be optimally effective. Rehabilitation is a promising adjunct therapy given the beneficial impact that physical activity and other training modalities can offer. Accordingly, "regenerative rehabilitation" is an emerging concentration of study, with the specific goal of improving positive functional outcomes by enhancing tissue restoration following injury. This article focuses on one emerging example of regenerative rehabilitation-namely, the integration of clinically based protocols with stem cell technologies following central nervous system injury. For the purposes of this review, the state of stem cell technologies for the central nervous system is summarized, and a rationale for a synergistic benefit of carefully orchestrated rehabilitation protocols in conjunction with cellular therapies is provided. An overview of practical steps to increase the involvement of physical therapy in regenerative rehabilitation research also is provided.

Indexed as

Physical Therapy ModalitiesRegenerationCentral Nervous System DiseasesCombined Modality TherapyHumansNeural Stem Cells

Identifiers

PMID26847015
PMCPMC6281018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.