ArticleAJNR. American journal of neuroradiology2016
Incidence of Radiologically Isolated Syndrome: A Population-Based Study.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Environmental risk factors and conversion to multiple sclerosis in subjects with radiologically isolated syndrome: a case-control study.Journal of neurology · 2026Article
- Radiologically isolated syndromes: to treat or not to treat?Journal of neurology · 2024Review
- Secondary Prevention in Radiologically Isolated Syndromes and Prodromal Stages of Multiple Sclerosis.Frontiers in neurology · 2022Review
- Radiologically isolated syndrome: from biological bases to practical management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Prevalence, Severity, and Clinical Management of Brain Incidental Findings in Healthy Young Adults: MRi-Share Cross-Sectional Study.Frontiers in neurology · 2021Article
- [Headache in multiple sclerosis].Der Nervenarzt · 2020Review
- Radiologically Isolated Syndrome: A Review for Neuroradiologists.AJNR. American journal of neuroradiology · 2020Review
- Structural and functional MRI correlates of T2 hyperintensities of brain white matter in young neurologically asymptomatic adults.European radiology · 2019Article
- The Central Vein Sign in Radiologically Isolated Syndrome.AJNR. American journal of neuroradiology · 2019Article
- [Diagnosis of multiple sclerosis: revision of the McDonald criteria 2017].Der Nervenarzt · 2018Review
- Does the radiologically isolated syndrome exist? A dual-task cost pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIncidental MR imaging findings resembling MS in asymptomatic individuals, fulfilling the Okuda criteria, are termed "radiologically isolated syndrome." Those with radiologically isolated syndrome are at high risk of their condition converting to MS. The epidemiology of radiologically isolated syndrome remains largely unknown, and there are no population-based studies, to our knowledge. Our aim was to study the population-based incidence of radiologically isolated syndrome in a high-incidence region for MS and to evaluate the effect on radiologically isolated syndrome incidence when revising the original radiologically isolated syndrome criteria by using the latest radiologic classification for dissemination in space. MATERIALS AND
methodsAll 2272 brain MR imaging scans in 1907 persons obtained during 2013 in the Swedish county of Västmanland, with a population of 259,000 inhabitants, were blindly evaluated by a senior radiologist and a senior neuroradiologist. The Okuda criteria for radiologically isolated syndrome were applied by using both the Barkhof and Swanton classifications for dissemination in space. Assessments of clinical data were performed by a radiology resident and a senior neurologist.
resultsThe cumulative incidence of radiologically isolated syndrome was 2 patients (0.1%), equaling an incidence rate of 0.8 cases per 100,000 person-years, in a region with an incidence rate of MS of 10.2 cases per 100,000 person-years. There was no difference in the radiologically isolated syndrome incidence rate when applying a modified version of the Okuda criteria by using the newer Swanton classification for dissemination in space.
conclusionsRadiologically isolated syndrome is uncommon in a high-incidence region for MS. Adapting the Okuda criteria to use the dissemination in space-Swanton classification may be feasible. Future studies on radiologically isolated syndrome may benefit from a collaborative approach to ensure adequate numbers of participants.
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