Evidence map›Paper›PMID 26846913›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2016

Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM).

Roberto Sciagrà, Alessandro Passeri, Jan Bucerius, Hein J Verberne, Riemer H J A Slart, Oliver Lindner, Alessia Gimelli, Fabien Hyafil, Denis Agostini, Christopher Übleis and 2 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Nuclear cardiology a solid pillar in the new chronic coronary syndromes ESC guidelines.European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Patient-tailored risk assessment of obstructive coronary artery disease using Rubidium-82 PET-based myocardial flow quantification with visual interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  4. Impact of [Diagnostics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Effect of temporal sampling protocols on myocardial blood flow measurements using Rubidium-82 PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  7. Review
  8. Value of SiPM PET in myocardial perfusion imaging using Rubidium-82.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  9. Body weight-dependent Rubidium-82 activity results in constant image quality in myocardial perfusion imaging with PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  10. The brain connection between stress and heart: a convincing research opportunity to reduce risk and gender disparity in cardiovascular disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  11. EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021
    Article
  12. Sub-endocardial and sub-epicardial measurement of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Observational
  13. Software reproducibility of myocardial blood flow and flow reserve quantification in ischemic heart disease: AJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  14. Article
  15. Impact of regadenoson-induced myocardial creep on dynamic Rubidium-82 PET myocardial blood flow quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  16. No need for frame-wise attenuation correction in dynamic Rubidium-82 PET for myocardial blood flow quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roberto SciagràNuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy. r.sciagra@dfc.unifi.it.
Alessandro PasseriNuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Jan BuceriusDepartment of Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Hein J VerberneDepartment of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Riemer H J A SlartDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands.
Oliver LindnerInstitute of Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.
Alessia GimelliFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Fabien HyafilDepartment of Nuclear Medicine, Bichat University Hospital, Assistance Publique - Hôpitaux de Paris, UMR 1148, Inserm and Paris Diderot-Paris 7 University, Département Hospitalo-Universitaire Fire, Paris, France.
Denis AgostiniLaboratoire de Biophysique Medicale Faculte de Medecine, Siemens Healthcare, Caen, France.
Christopher ÜbleisDepartment of Clinical Radiology, Ludwig-Maximilians Universität München, Munich, Germany.
Marcus HackerDepartment of Radiology and Nuclear Medicine, Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria.
Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Until recently, PET was regarded as a luxurious way of performing myocardial perfusion scintigraphy, with excellent image quality and diagnostic capabilities that hardly justified the additional cost and procedural effort. Quantitative perfusion PET was considered a major improvement over standard qualitative imaging, because it allows the measurement of parameters not otherwise available, but for many years its use was confined to academic and research settings. In recent years, however, several factors have contributed to the renewal of interest in quantitative perfusion PET, which has become a much more readily accessible technique due to progress in hardware and the availability of dedicated and user-friendly platforms and programs. In spite of this evolution and of the growing evidence that quantitative perfusion PET can play a role in the clinical setting, there are not yet clear indications for its clinical use. Therefore, the Cardiovascular Committee of the European Association of Nuclear Medicine, starting from the experience of its members, decided to examine the current literature on quantitative perfusion PET to (1) evaluate the rationale for its clinical use, (2) identify the main methodological requirements, (3) identify the remaining technical difficulties, (4) define the most reliable interpretation criteria, and finally (5) tentatively delineate currently acceptable and possibly appropriate clinical indications. The present position paper must be considered as a starting point aiming to promote a wider use of quantitative perfusion PET and to encourage the conception and execution of the studies needed to definitely establish its role in clinical practice.

Indexed as

Nuclear MedicineSocieties, MedicalCardiovascular SystemHumansImage Processing, Computer-AssistedPositron-Emission TomographyRadiopharmaceuticalsRadiopharmaceuticalsCoronary flow reserveMyocardial blood flowPositron emission tomography

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.