Evidence map›Paper›PMID 26846861›Full record

ArticleStroke2016

Nonpsychotic Mental Disorders in Teenage Males and Risk of Early Stroke: A Population-Based Study.

Maria A I Åberg, Kjell Torén, Michael Nilsson, Malin Henriksson, H Georg Kuhn, Jenny Nyberg, Annika Rosengren, N David Åberg, Margda Waern

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maria A I ÅbergFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.). maria.aberg@gu.se.
Kjell TorénFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
Michael NilssonFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
Malin HenrikssonFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
H Georg KuhnFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
Jenny NybergFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
Annika RosengrenFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
N David ÅbergFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
Margda WaernFrom the Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology (M.A.I.Å., M.N., M.H., H.G.K., J.N.), Department of Primary Health Care (M.A.I.Å., M.H.), Occupational and Environmental Medicine (K.T.), Departments of Molecular and Clinical Medicine (A.R.), Department of Internal Medicine (N.D.Å.), Institute of Medicine, Neuropsychiatric Epidemiology Unit, and Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (M.W.) Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia (M.N.).
Texas A&M Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAlthough the incidence of stroke is on the decline worldwide, this is not the case for early stroke. We aimed to determine whether nonpsychotic mental disorder at the age of 18 years is a risk factor for early stroke, and if adolescent cardiovascular fitness and intelligence quotient might attenuate the risk.

methodPopulation-based Swedish cohort study of conscripts (n=1 163 845) who enlisted during 1968 to 2005. At conscription, 45 064 males were diagnosed with nonpsychotic mental disorder. Risk of stroke during follow-up (5-42 years) was calculated with Cox proportional hazards models. Objective baseline measures of fitness and cognition were included in the models in a second set of analyses.

resultsThere were 7770 first-time stroke events. In adjusted models, increased risk for stroke was observed in men diagnosed with depressive/neurotic disorders (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.11-1.37), personality disorders (HR, 1.52; 95% CI, 1.29-1.78), and alcohol/substance use disorders (HR, 1.61; 95% CI, 1.41-1.83) at conscription. Corresponding figures for fatal stroke were HR, 1.38; 95% CI, 1.06 to 1.79; HR, 2.26; 95% CI, 1.60 to 3.19; and HR, 2.20; 95% CI, 1.63 to 2.96. HRs for stroke were attenuated when fitness level and intelligence quotient were introduced. Associations remained significant for personality disorders and alcohol/substance use in the fully adjusted models. The interaction term was statistically significant for fitness but not for intelligence quotient.

conclusionsOur findings suggest that fitness may modify associations between nonpsychotic disorders and stroke. It remains to be clarified whether interventions designed to improve fitness in mentally ill youth can influence future risk of early stroke.

Indexed as

Population SurveillanceAdolescentAge FactorsCohort StudiesFollow-Up StudiesHumansLongitudinal StudiesMaleMental DisordersRisk FactorsStrokeSwedenadolescentexercisemental disorderspopulationstroke

Identifiers

PMID26846861
PMCPMC4760382
OpenAlexW2262523993

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.