ReviewJournal of stroke2016
Moyamoya Disease: Treatment and Outcomes.
Review in Journal of stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03882060 (The Effect of Recombinant Human Erythropoietin on the Postoperative Neurologic Outcome in Pediatric Moyamoya Disease Patients - A Double Blind Randomized Controlled Trial), which is not on this map. Cited by 117 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Recombinant Human Erythropoietin on the Postoperative Neurologic Outcome in Pediatric Moyamoya Disease Patients - A Double Blind Randomized Controlled Trial
Who cites it
117 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Remote ischaemic conditioning for neurological disorders-a systematic review and narrative synthesis.Systematic reviews · 2024Pooled it
- Antiplatelet Treatment in Moyamoya Disease: A Systematic Review.Cerebrovascular diseases extra · 2024Pooled it
- Risk factors for postoperative stroke in adults patients with moyamoya disease: a systematic review with meta-analysis.BMC neurology · 2019Pooled it
- Clinical importance of the middle meningeal artery: A review of the literature.International journal of medical sciences · 2016Pooled it
- Gut microbial histamine and serotonin promote cerebrovascular angiogenesis: Evidence from moyamoya disease.Genes & diseases · 2027Article
- An unusual presentation of Moyamoya disease managed conservatively in a resource limited region: A case report.Radiology case reports · 2026Article
- Article
- Moyamoya Vasculopathy and Atypical Moyamoya-like Patterns: Insights into Diagnosis and Therapeutic Implications.NeuroSci · 2026Review
- Effect of encephalomyosynangiosis procedure on post stroke recovery in a permanent model of ischemic stroke.Experimental neurology · 2026Article
- Age-dependent associations of peripheral immune-inflammatory indices with cerebrovascular remodeling after revascularization in ischemic moyamoya disease.Frontiers in immunology · 2026Observational
- Intraoperative transit-time flowmetry of the superficial temporal artery directly predicts and may mitigate risk of postoperative hyperperfusion syndrome in moyamoya bypass surgery.Frontiers in neurology · 2026Article
- Distinct presentation of Moyamoya disease in Iran.European journal of translational myology · 2025Article
- Identification of Biomarkers Related to the Pathogenesis and Prognosis of Pediatric Moyamoya Disease Via Cerebrospinal Fluid Proteomics.Translational stroke research · 2025Article
- Multimodality Imaging of Moyamoya Disease: A Practical Guide for Neuroradiologists Based on a Case Report.Reports (MDPI) · 2025Article
- Moyamoya disease: epidemiology, clinical features, pathogenesis, diagnosis and therapeutic interventions.Molecular biomedicine · 2025Review
- Clinical significance of postoperative collateral circulation formation in long-term prognosis and stroke events after EDAS in adults with moyamoya disease.Neurosurgical review · 2025Article
- The role of the RING finger protein 213 gene in Moyamoya disease.Fluids and barriers of the CNS · 2025Review
- Article
- Stroke and associated comorbidities in Southeast Asian countries.Neuroprotection (Chichester, England) · 2025Review
- The Role of TCD in Assessing Postoperative Collateral Development and Long-Term Clinical Outcome in Moyamoya Disease.CNS neuroscience & therapeutics · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the pathogenesis of moyamoya disease (MMD) has not been fully elucidated, the effectiveness of surgical revascularization in preventing stroke has been addressed by many studies. The main mechanism of surgical revascularization is augmenting the intracranial blood flow using an external carotid system by either direct bypass or pial synangiosis. This can improve resting cerebral blood flow as well as vascular reserve capacity. For direct revascularization, the superficial temporal artery is used as the donor artery in most cases, although the occipital artery may be used in limited cases. Usually, the cortical branch of the middle cerebral artery is selected as the recipient of direct anastomosis. As for indirect revascularization, various techniques using different kinds of connective tissues have been introduced. In some cases, reinforcing the anterior cerebral artery and the posterior cerebral artery territories can be considered. The effectiveness of surgical revascularization for preventing ischemic stroke had been generally accepted by many studies. However, for preventing hemorrhagic stroke, new evidence has been added by a recent randomized controlled trial. The incidence of peri-operative complications such as stroke and hyperperfusion syndrome seems to be high due to the nature of the disease and technical demands for treatment. Preventing and adequately managing these complications are essential for ensuring the benefits of surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.