ReviewJournal of stroke2016
The Pathophysiology of Moyamoya Disease: An Update.
Review in Journal of stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03882060 (The Effect of Recombinant Human Erythropoietin on the Postoperative Neurologic Outcome in Pediatric Moyamoya Disease Patients - A Double Blind Randomized Controlled Trial), which is not on this map. Cited by 104 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Recombinant Human Erythropoietin on the Postoperative Neurologic Outcome in Pediatric Moyamoya Disease Patients - A Double Blind Randomized Controlled Trial
Who cites it
104 citing papers in PubMed, 3 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Efficacy of double anastomosis STA-MCA bypass in adult Moyamoya disease and cerebral atherosclerosis disease: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Pooled it
- Antiplatelet Treatment in Moyamoya Disease: A Systematic Review.Cerebrovascular diseases extra · 2024Pooled it
- Development and effects of salutogenesis program for adolescents with moyamoya disease: A randomized controlled trial.PloS one · 2023Trial
- Endothelial Progenitor Cells Induce Angiogenesis: a Potential Mechanism Underlying Neovascularization in Encephaloduroarteriosynangiosis.Translational stroke research · 2021Trial
- An Emerging Role of Artificial Intelligence in Pediatric Neuroanesthesia.Journal of Korean Neurosurgical Society · 2026Article
- Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.Biomedical reports · 2026Article
- How retinal artery occlusion reveals moyamoya disease-a case series and descriptive study.International journal of ophthalmology · 2026Article
- Potential neuroprotective role of dexmedetomidine in preventing postoperative cerebral hyperperfusion syndrome: from mechanisms to clinical applications.American journal of translational research · 2026Review
- Article
- Increased plasma fibronectin mirrors intimal phenotypic switching of vascular smooth muscle cells in moyamoya arteriopathy.Scientific reports · 2025Article
- MicroRNA-29b-3p promotes endothelial cell inflammation via NTRK2/PI3K/NLRP3 pathway in Moyamoya disease.European journal of medical research · 2025Article
- Multimodality Imaging of Moyamoya Disease: A Practical Guide for Neuroradiologists Based on a Case Report.Reports (MDPI) · 2025Article
- Systemic Vasculopathy Associated With HomozygousJournal of Korean medical science · 2025Article
- A ruptured de novo anastomotic aneurysm shortly after superficial temporal artery-to-middle cerebral artery bypass surgery in a patient with moyamoya disease: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Genome-Wide DNA Methylation Profiling Reveals Low Methylation Variability in Moyamoya Disease.Translational stroke research · 2025Article
- Long-term follow-up of moyamoya disease in a patient with a duplicated middle cerebral artery: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Coexistence of moyamoya disease and subclavian steal syndrome.Acta neurologica Belgica · 2025Article
- The role of the RING finger protein 213 gene in Moyamoya disease.Fluids and barriers of the CNS · 2025Review
- Comprehensive Analysis and In Vitro Verification of Endothelial-Mesenchymal Transition-Related Genes in Moyamoya Disease.Molecular neurobiology · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moyamoya disease (MMD) is a unique cerebrovascular disease characterized by the progressive stenosis of large intracranial arteries and a hazy network of basal collaterals called moyamoya vessels. Because the etiology of MMD is unknown, its diagnosis is based on characteristic angiographic findings. Re-vascularization techniques (e.g., bypass surgery) are used to restore perfusion, and are the primary treatment for MMD. There is no specific treatment to prevent MMD progression. This review summarizes the recent advances in MMD pathophysiology, including the genetic and circulating factors related to disease development. Genetic and environmental factors may play important roles in the development of the vascular stenosis and aberrant angiogenesis in complex ways. These factors include the related changes in circulating endothelial/smooth muscle progenitor cells, cytokines related to vascular remodeling and angiogenesis, and endothelium, such as caveolin which is a plasma membrane protein. With a better understanding of MMD pathophysiology, nonsurgical approaches targeting MMD pathogenesis may be available to stop or slow the progression of this disease. The possible strategies include targeting growth factors, retinoic acid, caveolin-1, and stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.