ReviewJournal of stroke2016
Moyamoya Disease: Epidemiology, Clinical Features, and Diagnosis.
Review in Journal of stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
234 citing papers in PubMed, 10 syntheses or guidelines pooled it, 478 citations in OpenAlex.
- Incidence of cerebral hyperperfusion syndrome following revascularization surgery in moyamoya patients: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Differentially Expressed Genes and Biological Pathways in Moyamoya Disease: A Systematic Review and Meta-analysis of Transcriptomic Studies.Translational stroke research · 2025Pooled it
- Complications associated with combined direct and indirect bypass in Moyamoya Disease: A meta-analysis.Neurosurgical review · 2024Pooled it
- Psychiatric manifestations in moyamoya disease: more than a puff of smoke? a systematic review and a case-reports meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Association of moyamoya vasculopathy with autoimmune disease: a systematic review and pooled analysis.Neurosurgical review · 2023Pooled it
- Antiplatelet therapy may improve the prognosis of patients with moyamoya disease: a 12-year retrospective study.Journal of neurology · 2023Pooled it
- Potential predictors for progression of moyamoya disease: A systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Central nervous system vasculopathy and Seckel syndrome: case illustration and systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Pooled it
- Pediatric Acute Ischemic Stroke by Age-Group: A Systematic Review and Meta-Analysis of Published Studies and Hospitalization Records.Neuroepidemiology · 2021Pooled it
- Mapping Trends in Moyamoya Angiopathy Research: A 10-Year Bibliometric and Visualization-Based Analyses of the Web of Science Core Collection (WoSCC).Frontiers in neurology · 2021Pooled it
- Noninvasive Assessment of the Risk Features of Hemorrhage in Moyamoya Disease Using 7T MRI.Neurology · 2025Trial
- Safety analysis of STA-MCA bypass combined with EDAS in the treatment of patients with moyamoya disease.Medicine · 2025Trial
- Integrated analysis of the association between methionine cycle and risk of moyamoya disease.CNS neuroscience & therapeutics · 2023Trial
- Development and effects of salutogenesis program for adolescents with moyamoya disease: A randomized controlled trial.PloS one · 2023Trial
- Moyamoya disease presenting as galactorrhea.JCEM case reports · 2026Article
- An unusual presentation of Moyamoya disease managed conservatively in a resource limited region: A case report.Radiology case reports · 2026Article
- Single-Barrel versus Double-Barrel Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Moyamoya Disease: A Systematic Review and Meta-Analysis of Postoperative Stroke Outcomes.Journal of neurological surgery. Part B, Skull base · 2026Article
- Anesthetic Management for Encephaloduroarteriosynangiosis in Moyamoya Disease: A Hemodynamic and Neuromonitoring-Integrated Framework.Journal of clinical medicine · 2026Review
- Clinical Efficacy of Revascularization Surgery for Moyamoya Angiopathy: Long-Term Results of a European Cohort.European journal of neurology · 2026Article
- Deep learning reconstruction enhances 1.5T MR angiography beyond 3T in vascular visualization for Moyamoya disease.Japanese journal of radiology · 2026Article
174 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moyamoya disease (MMD) is a chronic, occlusive cerebrovascular disease characterized by progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its etiology remains unknown, recent genetic studies identified RNF213 in the 17q25-ter region as an important susceptibility gene of MMD among East Asian populations. Possibly because of genetic differences, MMD is relatively common in people living in East Asian countries such as Korea and Japan, compared to those in the Western Hemisphere. The prevalence of MMD appears to be slightly lower among Chinese, compared to Koreans or Japanese. There are two peaks of incidence with different clinical presentations, at around 10 years and 30-40 years. The peak appears to occur later in women than men. In children, ischemic symptoms, especially transient ischemic attacks, are predominant. Intellectual decline, seizures, and involuntary movements are also more common in this age group. In contrast, adult patients present with intracranial hemorrhage more often than pediatric patients. In patients with MMD, intracerebral hemorrhage is more often accompanied by intraventricular hemorrhage than in patients with hypertensive intracerebral hemorrhage. These different age peaks and different clinical presentations in each age group are also observed in MMD patients in the USA. Catheter angiography is the diagnostic method of choice. Magnetic resonance (MR) angiography and computed tomographic angiography are noninvasive diagnostic methods. High-resolution vessel wall MR imaging also helps diagnose MMD by revealing concentric vessel wall narrowing with basal collaterals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.