Evidence map›Paper›PMID 26846711›Full record

ArticleDento maxillo facial radiology2016

Quantitative dynamic contrast-enhanced and diffusion-weighted MRI for differentiation between nasopharyngeal carcinoma and lymphoma at the primary site.

Xiao-ping Yu, Jing Hou, Fei-ping Li, Wang Xiang, Qiang Lu, Yin Hu, Hui Wang

Abstract readComparative Study
In one paragraph

Article in Dento maxillo facial radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao-ping Yu1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
Jing Hou1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
Fei-ping Li1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
Wang Xiang1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
Qiang Lu1 Department of Diagnostic Radiology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
Yin Hu3 Department of Diagnostic Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.
Hui Wang3 Department of Diagnostic Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the value of quantitative dynamic contrast-enhanced MRI (QDCE-MRI) and diffusion-weighted MRI (DW-MRI) in differentiating nasopharyngeal carcinoma (NPC) from lymphoma.

methodsWe retrospectively analysed the data from 102 patients (82 with NPC and 20 with lymphoma) who underwent pre-treatment QDCE-MRI and DW-MRI on a 1.5-T MR unit. QDEC-MRI parameters [influx transfer constant (K(trans)), efflux rate constant (Kep), fractional volume of extravascular extracellular space (Ve) and fractional volume of plasma (fPV)] based on pharmacokinetic model and apparent diffusion coefficient (ADC) were compared between the two nasopharyngeal malignancies.

resultsThe K(trans), Kep, Ve, fPV and ADC values (mean ± standard deviation) for NPC were 0.366 ± 0.155 min(-1), 1.353 ± 0.468 min(-1), 0.292 ± 0.117, 0.027 ± 0.024 and 0.981 ± 0.184 × 10(-3) mm(2) s(-1), respectively. The K(trans), Kep, Ve, fPV and ADC values (mean ± standard deviation) for lymphoma were 0.212 ± 0.059 min(-1), 1.073 ± 0.238 min(-1), 0.213 ± 0.104, 0.008 ± 0.007 and 0.760 ± 0.182 × 10(-3) mm(2) s(-1), respectively. Optimal cut-off values (area under the curve, sensitivity, specificity) for distinguishing the two tumours were as follows: K(trans) = 0.262 min(-1) (0.866, 80.49%, 85.00%), Kep = 1.401 min(-1) (0.681, 43.90%, 100.00%), Ve = 0.211 (0.784, 76.83%, 85.00%), fPV = 0.012 (0.779, 60.98%, 85.00%), ADC = 0.761 × 10(-3) mm(2) s(-1) (0.781, 93.90%, 55.00%).

conclusionsQDCE-MRI together with DW-MRI is useful for differentiation between NPC and lymphoma.

Indexed as

Contrast MediaArea Under CurveCarcinomaDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingHumansImage EnhancementImage Processing, Computer-AssistedLymphomaLymphoma, B-CellLymphoma, T-CellMagnetic Resonance ImagingNasopharyngeal NeoplasmsRetrospective StudiesSensitivity and SpecificityContrast Mediadiffusion-weighted imagingdynamic contrast-enhanced magnetic resonance imagingnasopharyngeal carcinomanasopharyngeal lymphomasensitivity and specificity

Identifiers

PMID26846711
PMCPMC4846150

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.