Evidence map›Paper›PMID 26846575›Full record

ArticleScientific reports2016

Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.

Aya Aoki, Maiko Inoue, Elizabeth Nguyen, Ryo Obata, Kazuaki Kadonosono, Shoji Shinkai, Hideki Hashimoto, Satoshi Sasaki, Yasuo Yanagi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Aya AokiDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Maiko InoueYokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Elizabeth NguyenDepartment of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.
Ryo ObataDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kazuaki KadonosonoYokohama City University Medical Center, Yokohama, Kanagawa, Japan.
Shoji ShinkaiTokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Hideki HashimotoDepartment of Health Economics and Epidemiology Research, University of Tokyo School of Public Health, Tokyo, Japan.
Satoshi SasakiDepartment of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan.
Yasuo YanagiDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPTokyo Metropolitan Institute of Gerontology · JPUniversity of Tokyo Health Sciences · JPYokohama City University · JPYokohama City University Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case-control study reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) in Japan. The nutrient intake of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects from a cohort study was assessed using a brief-type self-administered questionnaire on diet history, which required respondent recall of the usual intake of 58 foods during the preceding month. Energy-adjusted nutrient intake values were compared between the groups. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% CIs adjusted for smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption. Logistic regression analysis demonstrated that low intakes of n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene were associated with neovascular AMD (Trend P < 0.0001 for n-3 fatty acid, Trend P < 0.0001 for α-tocopherol, Trend P < 0.0001 for zinc, Trend P = 0.002 for vitamin D, Trend P = 0.04 for vitamin C, Trend P = 0.0004 for β-carotene). There was no association with retinol or cryptoxanthin intake and neovascular AMD (P = 0.67, 0.06).

Indexed as

AgedAged, 80 and overalpha-TocopherolAscorbic Acidbeta CaroteneCase-Control StudiesDietary SupplementsEnergy IntakeFatty Acids, Omega-3FemaleHumansJapanLogistic ModelsMacular DegenerationMaleRisk Factorsalpha-TocopherolAscorbic Acidbeta CaroteneFatty Acids, Omega-3Vitamin DZinc

Identifiers

PMID26846575
PMCPMC4742947
OpenAlexW2413096074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.