ArticleBMC medical research methodology2016
Eliciting parental support for the use of newborn blood spots for pediatric research.
Article in BMC medical research methodology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Maternal antenatal depression and offspring DNA methylation.Journal of affective disorders · 2026Article
- Cohort Profile: Upstate KIDS study.International journal of epidemiology · 2025Article
- A comprehensive approach for detection of biotin deficiency from dried blood spot samples using liquid chromatography-mass spectrometry.Future science OA · 2024Article
- Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism.Epigenetics · 2023Article
- Epigenetic gestational age and the relationship with developmental milestones in early childhood.Human molecular genetics · 2023Article
- Effects on neonatal immunoglobulin concentrations by infant mode of delivery in the upstate KIDS study (2008-2010).American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- The view of Hong Kong parents on secondary use of dried blood spots in newborn screening program.BMC medical ethics · 2022Article
- Exposure to perfluoroalkyl substances and neonatal immunoglobulin profiles in the upstate KIDS study (2008-2010).Environmental pollution (Barking, Essex : 1987) · 2022Article
- Conception by fertility treatment and offspring deoxyribonucleic acid methylation.Fertility and sterility · 2021Article
- The use of dried blood spots for characterizing children's exposure to organic environmental chemicals.Environmental research · 2021Review
- Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort.Environmental research · 2021Article
- Little to Give, Much to Gain-What Can You Do With a Dried Blood Spot?Current environmental health reports · 2020Review
- Exposure to Persistent Organic Pollutants and Birth Characteristics: The Upstate KIDS Study.Epidemiology (Cambridge, Mass.) · 2019Article
- Examining Endocrine Disruptors Measured in Newborn Dried Blood Spots and Early Childhood Growth in a Prospective Cohort.Obesity (Silver Spring, Md.) · 2019Article
- Concentrations of endocrine disrupting chemicals in newborn blood spots and infant outcomes in the upstate KIDS study.Environment international · 2018Article
- Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior.Environmental pollution (Barking, Essex : 1987) · 2018Article
- Newborn adipokines and early childhood growth.Pediatric obesity · 2018Article
- Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study.Paediatric and perinatal epidemiology · 2018Article
- Determinants of neonatal brain-derived neurotrophic factor and association with child development.Development and psychopathology · 2017Article
- Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundBiomarkers of exposures such as infection or environmental chemicals can be measured in small volumes of blood extracted from newborn dried blood spots (DBS) underscoring their potential utility for population-based research. However, few studies have evaluated the feasibility and utility of this resource; particularly the factors associated with parental consent, and the ability to retrieve banked samples with sufficient remaining volume for epidemiologic research.
methodsAt 8 months postpartum, 5,034 mothers of infants born (2008-2010) in New York (57 counties excluding New York City) were asked to consent for the use of residual DBS for the quantification of cytokines and environmental chemicals. Mothers were part of the Upstate KIDS study, a longitudinal birth cohort designed to evaluate child development through 3 years of age. Information on parental and infant characteristics was obtained from birth certificates and maternal report at 4 months postpartum. Multivariate logistic regression was used to identify factors associated with parental consent and with successful retrieval of DBS.
resultsSixty-two percent (n = 3125) of parents consented. Factors significantly associated with consent included non-Hispanic ethnicity (odds ratio 2.04; 95% CI: 1.43-2.94), parity (1.29; 1.05-1.57), maternal obesity (1.42; 1.11-1.80) and reported alcohol use during pregnancy (1.51; 1.12-2.06). However, these associations corresponded to small absolute differences in proportions (4 to 8%), suggesting that the two groups remained comparable. Infant characteristics such as preterm delivery did not significantly differ by consent status among singletons and only ventilator use (OR 2.39; 95% CI: 1.06-5.41) remained borderline significant among twins in adjusted analyses. Among consented infants, 99% had at least one 3.2 mm punch successfully retrieved for biomarker analyses and 84% had a full DBS circle available.
conclusionParental characteristics varied slightly by consent, and the availability of samples for research purposes was high, demonstrating the feasibility of this resource for population based research.
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