Evidence map›Paper›PMID 26846219›Full record

ArticleJournal of behavioral medicine2016

Endocrine dysregulation in women with irritable bowel syndrome according to Rome II criteria.

Charlotte Markert, Kerstin Suarez-Hitz, Ulrike Ehlert, Urs M Nater

Abstract read
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In one paragraph

Article in Journal of behavioral medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charlotte MarkertDepartment of Psychology, Clinical Biopsychology, University of Marburg, Gutenbergstr.18, 35032, Marburg, Germany. markert@staff.uni-marburg.de.
Kerstin Suarez-HitzDepartment of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmühlestr.14, 8050, Zurich, Switzerland.
Ulrike EhlertDepartment of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Binzmühlestr.14, 8050, Zurich, Switzerland.
Urs M NaterDepartment of Psychology, Clinical Biopsychology, University of Marburg, Gutenbergstr.18, 35032, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology of the irritable bowel syndrome (IBS) is unexplained: biological, psychological and social factors must be considered. This study examined if differences in HPA-axis activity already exist in those who do not yet fulfill IBS criteria (i.e. "subthreshold IBS"). We also investigated whether there were differences between those who reported clinically relevant (i.e. distressing) IBS symptoms and those who did not. Thirty-six women were subdivided into three groups (IBS group, subthreshold IBS group, control group). Results showed differences in morning cortisol levels (U = 11.58; p < 0.05), with IBS patients showing a lower cortisol response compared to controls. Subthreshold IBS patients were comparable to controls regarding endocrine function. Diurnal cortisol levels did not differ between groups. Group comparisons between distressed subjects and non-distressed subjects regarding cortisol levels did not reach significance. The finding of endocrine abnormalities (at least in a sub-set of patients) is important since these might be associated with deficient pain processing in IBS.

Indexed as

AdultFemaleHumansHydrocortisoneIrritable Bowel SyndromeSalivaSeverity of Illness IndexStress, PsychologicalYoung AdultHydrocortisoneCortisol awakening responseDistressIrritable bowel syndromeRome II criteriaRome III criteria

Identifiers

PMID26846219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.