ReviewNeurochemical research2016
The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions.
Review in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Therapeutic Potential of Ellagic Acid in Liver Diseases.Molecules (Basel, Switzerland) · 2025Review
- Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review.Frontiers in pharmacology · 2025Review
- Article
- A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics.Antioxidants (Basel, Switzerland) · 2024Review
- Review
- Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies.IET nanobiotechnology · 2023Article
- Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain.Metabolic brain disease · 2023Article
- Oral ellagic acid attenuated LPS-induced neuroinflammation in rat brain: MEK1 interaction and M2 microglial polarization.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice.Heliyon · 2023Article
- Ellagic Acid and Its Anti-Aging Effects on Central Nervous System.International journal of molecular sciences · 2022Review
- Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential.Oxidative medicine and cellular longevity · 2022Review
- Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy.International journal of molecular sciences · 2021Article
- Presynaptic Release-Regulating Alpha2 Autoreceptors: Potential Molecular Target for Ellagic Acid Nutraceutical Properties.Antioxidants (Basel, Switzerland) · 2021Article
- Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington's disease.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Neuroprotective Potential of Ellagic Acid: A Critical Review.Advances in nutrition (Bethesda, Md.) · 2021Review
- Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries.Molecules (Basel, Switzerland) · 2021Article
- Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review.Frontiers in pharmacology · 2021Review
- Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson's Disease.Biomolecules · 2020Article
- Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?Antioxidants (Basel, Switzerland) · 2020Review
- Pharmacological safety ofToxicology reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports is still limited to conclude whether and how EA exerts neuroprotection in humans. In this regard, performing additional studies considering the potential beneficial and/or toxicological roles for EA on brain cells would be an important step towards fully understanding of when and how EA may be securely utilized by humans as a neuroprotective agent. The aim of the present work is to discuss data related to the neuronal and glial effects of EA and the mechanisms underlying such events. Moreover, future directions are suggested as a potential guide to be utilized by researchers interested in investigating the neuronal and glial actions of EA hereafter.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.