ArticlePloS one2016
Genomic Signatures for Avian H7N9 Viruses Adapting to Humans.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Mutual information networks reveal evolutionary relationships within the influenza A virus polymerase.bioRxiv : the preprint server for biology · 2023Article
- Mutual information networks reveal evolutionary relationships within the influenza A virus polymerase.Virus evolution · 2023Article
- Antigenic Characterization of Neuraminidase of Influenza A/H7N9 Viruses Isolated in Different Years.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- H7N9 bearing a mutation in the nucleoprotein leads to increased pathology in chickens.Frontiers in immunology · 2022Article
- Emergence of a Novel Reassortant H5N3 Avian Influenza Virus in Korean Mallard Ducks in 2018.Intervirology · 2022Article
- The viral distribution and pathological characteristics of BALB/c mice infected with highly pathogenic Influenza H7N9 virus.Virology journal · 2021Article
- H7N9 Influenza Virus in China.Cold Spring Harbor perspectives in medicine · 2021Review
- Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China.PLoS pathogens · 2021Article
- Novel pathogenic characteristics of highly pathogenic avian influenza virus H7N9: viraemia and extrapulmonary infection.Emerging microbes & infections · 2020Article
- Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong.Virus evolution · 2020Article
- Article
- Research progress on human infection with avian influenza H7N9.Frontiers of medicine · 2020Review
- Inventory of molecular markers affecting biological characteristics of avian influenza A viruses.Virus genes · 2019Review
- The 1918 influenza pandemic: 100 years of questions answered and unanswered.Science translational medicine · 2019Review
- Article
- Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.Emerging microbes & infections · 2018Article
- A pilot study on primary cultures of human respiratory tract epithelial cells to predict patients' responses to H7N9 infection.Oncotarget · 2018Article
- Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination With a Tri-Component Influenza Vaccine Using a Microneedle Patch.Frontiers in immunology · 2018Article
- Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An avian influenza A H7N9 virus emerged in March 2013 and caused a remarkable number of human fatalities. Genome variability in these viruses may provide insights into host adaptability. We scanned over 140 genomes of the H7N9 viruses isolated from humans and identified 104 positions that exhibited seven or more amino acid substitutions. Approximately half of these substitutions were identified in the influenza ribonucleoprotein (RNP) complex. Although PB2 627K of the avian virus promotes replication in humans, 45 of the 147 investigated PB2 sequences retained the E signature at this position, which is an avian characteristic. We discovered 10 PB2 substitutions that covaried with K627E. An RNP activity assay showed that Q591K, D701N, and M535L restored the polymerase activity in human cells when 627K transformed to an avian-like E. Genomic analysis of the human-isolated avian influenza virus is crucial in assessing genome variability, because relationships between position-specific variations can be observed and explored. In this study, we observed alternative positions that can potentially compensate for PB2 627K, a well-known marker for cross-species infection. An RNP assay suggested Q591K, D701N, and M535L as potential markers for an H7N9 virus capable of infecting humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.