ArticleACS chemical biology2016
Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.
Article in ACS chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.Communications biology · 2026Article
- Zebrafish as a translational filter for natural sleep modulators.Frontiers in nutrition · 2026Review
- High-throughput multi-camera array microscope platform for automated 3D behavioral analysis of swimming zebrafish larvae.bioRxiv : the preprint server for biology · 2025Article
- Behavioral Profiling in Zebrafish Identifies Insecticide-Related Compounds.Journal of agricultural and food chemistry · 2025Article
- Article
- A Multimodal, In Vivo Approach for Assessing Structurally and Phenotypically Related Neuroactive Molecules.ACS chemical neuroscience · 2024Article
- Deep phenotypic profiling of neuroactive drugs in larval zebrafish.Nature communications · 2024Article
- High throughput embryonic zebrafish test with automated dechorionation to evaluate nanomaterial toxicity.PloS one · 2022Article
- Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials.Nature reviews. Drug discovery · 2021Review
- Chemical Genetics: Manipulating the Germline with Small Molecules.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Assessment of zebrafish embryo photomotor response sensitivity and phase-specific patterns following acute- and long-duration exposure to neurotoxic chemicals and chemical weapon precursors.Journal of applied toxicology : JAT · 2020Article
- Article
- Towards High-Throughput Chemobehavioural Phenomics in Neuropsychiatric Drug Discovery.Marine drugs · 2019Review
- Impact of digital video analytics on accuracy of chemobehavioural phenotyping in aquatic toxicology.PeerJ · 2019Article
- Article
- Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).Behavioral and brain functions : BBF · 2018Article
- Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish.Toxicology and applied pharmacology · 2018Article
- Zebrafish: A Pharmacogenetic Model for Anesthesia.Methods in enzymology · 2018Article
- LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Physiological reviews · 2017Review
- Zebrafish models in neuropsychopharmacology and CNS drug discovery.British journal of pharmacology · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Many psychiatric drugs modulate the nervous system through multitarget mechanisms. However, systematic identification of multitarget compounds has been difficult using traditional in vitro screening assays. New approaches to phenotypic profiling in zebrafish can help researchers identify novel compounds with complex polypharmacology. For example, large-scale behavior-based chemical screens can rapidly identify large numbers of structurally diverse and phenotype-related compounds. Once these compounds have been identified, a systems-level analysis of their structures may help to identify statistically enriched target pathways. Together, systematic behavioral profiling and multitarget predictions may help researchers identify new behavior-modifying pathways and CNS therapeutics.
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Registered trials
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