ArticleJournal of abnormal psychology2016
Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use.
Article in Journal of abnormal psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Effects of an Alcohol-Related Harm Prevention Program among Out-of-School Female Adolescents.International journal of environmental research and public health · 2021Trial
- Pathways to substance use: Examining conduct problems and parenting behaviors from preschool to adolescence.Development and psychopathology · 2024Article
- Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.Development and psychopathology · 2024Article
- Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction.Substance abuse and rehabilitation · 2024Article
- Coping strategies as mediating mechanisms between adolescent polysubstance use classes and adult alcohol and substance use disorders.Addictive behaviors · 2023Article
- The role of parenting in developmental trajectories of risk for adolescent substance use: a bioecological systems cascade model.Frontiers in psychology · 2023Article
- The externalizing and internalizing pathways to marijuana use initiation: Examining the synergistic effects of impulsiveness and sensation seeking.Developmental psychology · 2021Article
- Temperament and character traits in substance use disorder in Iran: a case control study.BMC psychology · 2021Article
- Article
- Substance Use Outcomes from Two Formats of a Cognitive-Behavioral Intervention for Aggressive Children: Moderating Roles of Inhibitory Control and Intervention Engagement.Brain sciences · 2021Article
- Exploring pathways to substance use: A longitudinal examination of adolescent sport involvement, aggression, and peer substance use.Addictive behaviors · 2020Article
- Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study.Journal of youth and adolescence · 2020Article
- The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.Current addiction reports · 2019Article
- Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors.Development and psychopathology · 2019Article
- Predicting Behavior Problems in Korean Preschoolers: Interactions of theClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2018Article
- Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk.Development and psychopathology · 2018Article
- Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use.Journal of abnormal psychology · 2018Article
- Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations.Alcoholism, clinical and experimental research · 2017Article
- An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.Molecular psychiatry · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Understanding how specific genes contribute to risk for addiction remains challenging. This study tests whether childhood temperament and externalizing behavior in early adolescence account for a portion of the association between specific genetic variants and substance use problems in late adolescence. The sample consisted of 487 adolescents from the Michigan Longitudinal Study, a high-risk sample (70.2% male, 81.7% European American ancestry). Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. The temperament traits behavioral control and resiliency were assessed using interviewer ratings (ages 9-11), and externalizing behavior (ages 12-14) was assessed using teacher ratings. Self-reported substance use outcomes (ages 15-17) included maximum alcoholic beverages consumed in 24 hours, and frequency of past year cigarette and marijuana use. Behavioral control, resiliency, and externalizing behavior accounted for the associations between polymorphisms in noradrenergic and GABAergic genes and substance use in late adolescence. Individual differences in emotional coping and behavioral regulation represent nonspecific neurobiological underpinnings for an externalizing pathway to addiction. (PsycINFO Database Record
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