Evidence map›Paper›PMID 26845064›Full record

ReviewThe Journal of physiology2016

Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex.

Paula Q Barrett, Nick A Guagliardo, Peter M Klein, Changlong Hu, David T Breault, Mark P Beenhakker

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Lipid metabolism in the adrenal gland.Frontiers in endocrinology · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. CACNA1D-Related Channelopathies: From Hypertension to Autism.Handbook of experimental pharmacology · 2023
    Review
  8. Article
  9. Diseases caused by mutations in the NaAmerican journal of physiology. Cell physiology · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. De novo CACNA1D CaPflugers Archiv : European journal of physiology · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Paula Q BarrettDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22947, USA.
Nick A GuagliardoDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22947, USA.
Peter M KleinDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22947, USA.
Changlong HuDepartment of Physiology and Biophysics, School of Life Sciences, Institutes of Brain Science, Fudan University, Shanghai, 200433, China.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.
Mark P BeenhakkerDepartment of Pharmacology, University of Virginia, Charlottesville, VA, 22947, USA. mpb5y@virginia.edu.
University of Virginia · USBoston Children's Hospital · USFudan University · CN

Funding

T TYPE CALCIUM CHANNELS AND ALDOSTERONE SECRETIONR01HL036977 · NHLBI · YALE UNIVERSITY · PI BARRETT, PAULA Q · 1987 to 2013
$4.2M
Two-Pore Domain Potassium Channels and Aldosterone SecretionR01HL089717 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARRETT, PAULA Q, BAYLISS, DOUGLAS A. · 2008 to 2017
$3.4M
NHLBI NIH HHS R01 HL036977NHLBI NIH HHS R01 HL089717
6 · The paper itself

Abstract

Zona glomerulosa cells (ZG) of the adrenal gland constantly integrate fluctuating ionic, hormonal and paracrine signals to control the synthesis and secretion of aldosterone. These signals modulate Ca

Indexed as

Adrenal CortexAldosteroneAnimalsCalciumCalcium ChannelsHumansZona GlomerulosaAldosteroneCalciumCalcium Channels

Identifiers

PMID26845064
PMCPMC5063946
OpenAlexW2342974630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.