ArticleThe New phytologist2016
Transcript level coordination of carbon pathways during silicon starvation-induced lipid accumulation in the diatom Thalassiosira pseudonana.
Article in The New phytologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- The mosaic of aquatic photorespiration: evolution, diversity, and global biogeochemical impacts.The New phytologist · 2026Review
- Silicon uptake via the transporters SySIT-L and SyLsi-L enhances the growth and photosynthesis ofmBio · 2025Article
- Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation.Biological reviews of the Cambridge Philosophical Society · 2025Review
- A Non-Specific Phytohormone Regulatory Network inPlants (Basel, Switzerland) · 2025Article
- Molecular forecasting of domoic acid during a pervasive toxic diatom bloom.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Influence of Nutrient Deprivation on the Antioxidant Capacity and Chemical Profile of Two Diatoms from GenusMarine drugs · 2024Article
- The V-type ATPase enhances photosynthesis in marine phytoplankton and further links phagocytosis to symbiogenesis.Current biology : CB · 2023Article
- Improving the genome and proteome annotations of the marine model diatomMarine life science & technology · 2023Article
- Characterization of the molecular mechanisms of silicon uptake in coccolithophores.Environmental microbiology · 2023Article
- Nitrogen and Iron Availability Drive Metabolic Remodeling and Natural Selection of Diverse Phytoplankton during Experimental Upwelling.mSystems · 2022Article
- Diminished carbon and nitrate assimilation drive changes in diatom elemental stoichiometry independent of silicification in an iron-limited assemblage.ISME communications · 2022Article
- Enhancing microalgal lipid accumulation for biofuel production.Frontiers in microbiology · 2022Review
- Current perspectives on integrated approaches to enhance lipid accumulation in microalgae.3 Biotech · 2021Review
- A Review of Diatom Lipid Droplets.Biology · 2020Review
- Comparative Proteomic Analysis Reveals New Insights Into the Common and Specific Metabolic Regulation of the DiatomFrontiers in plant science · 2020Article
- Transcription profiles reveal the regulatory mechanisms of spur bud changes and flower induction in response to shoot bending in apple (Malus domestica Borkh.).Plant molecular biology · 2019Article
- Associated Bacteria Affect Sexual Reproduction by Altering Gene Expression and Metabolic Processes in a Biofilm Inhabiting Diatom.Frontiers in microbiology · 2019Article
- Proteomic study uncovers molecular principles of single-cell-level phenotypic heterogeneity in lipid storage ofBiotechnology for biofuels · 2019Article
- Reduced vacuolar β-1,3-glucan synthesis affects carbohydrate metabolism as well as plastid homeostasis and structure inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Quantitative Proteomics Reveals Common and Specific Responses of a Marine DiatomFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatoms are one of the most productive and successful photosynthetic taxa on Earth and possess attributes such as rapid growth rates and production of lipids, making them candidate sources of renewable fuels. Despite their significance, few details of the mechanisms used to regulate growth and carbon metabolism are currently known, hindering metabolic engineering approaches to enhance productivity. To characterize the transcript level component of metabolic regulation, genome-wide changes in transcript abundance were documented in the model diatom Thalassiosira pseudonana on a time-course of silicon starvation. Growth, cell cycle progression, chloroplast replication, fatty acid composition, pigmentation, and photosynthetic parameters were characterized alongside lipid accumulation. Extensive coordination of large suites of genes was observed, highlighting the existence of clusters of coregulated genes as a key feature of global gene regulation in T. pseudonana. The identity of key enzymes for carbon metabolic pathway inputs (photosynthesis) and outputs (growth and storage) reveals these clusters are organized to synchronize these processes. Coordinated transcript level responses to silicon starvation are probably driven by signals linked to cell cycle progression and shifts in photophysiology. A mechanistic understanding of how this is accomplished will aid efforts to engineer metabolism for development of algal-derived biofuels.
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