ReviewProgress in neurobiology2017
The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders.
Review in Progress in neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Dedifferentiation-like reprogramming of degenerative nucleus pulposus cells into notochordal-like cells by defined factors.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Review
- Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke.Frontiers of medicine · 2022Article
- A comparative study on the secretion of various cytokines by pulp stem cells at different passages and their neurogenic potential.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022Article
- Immunological Responses to Transgene-Modified Neural Stem Cells After Transplantation.Frontiers in immunology · 2021Article
- Characteristics, Classification, and Application of Stem Cells Derived from Human Teeth.Stem cells international · 2021Review
- Novel carbon film induces precocious calcium oscillation to promote neuronal cell maturation.Scientific reports · 2020Article
- Recent Overview of the Use of iPSCs Huntington's Disease Modeling and Therapy.International journal of molecular sciences · 2020Review
- Regeneration ThroughFrontiers in cellular neuroscience · 2020Review
- Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts.Translational neurodegeneration · 2020Article
- Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain.Frontiers in neurology · 2020Review
- Genomics and Transcriptomics: The Powerful Technologies in Precision Medicine.International journal of general medicine · 2020Review
- Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain.Stem cell reports · 2018Article
- Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons.Translational neurodegeneration · 2018Article
- Reprogramming Glia Into Neurons in the Peripheral Auditory System as a Solution for Sensorineural Hearing Loss: Lessons From the Central Nervous System.Frontiers in molecular neuroscience · 2018Review
- Representing Diversity in the Dish: Using Patient-DerivedFrontiers in neuroscience · 2018Review
- Engineering new neurons: in vivo reprogramming in mammalian brain and spinal cord.Cell and tissue research · 2018Review
- The Role of Stem Cells in the Treatment of Cerebral Palsy: a Review.Molecular neurobiology · 2017Review
- Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases.Stem cells international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Neural cell identity reprogramming strategies aim to treat age-related neurodegenerative disorders with newly induced neurons that regenerate neural architecture and functional circuits in vivo. The isolation and neural differentiation of pluripotent embryonic stem cells provided the first in vitro models of human neurodegenerative disease. Investigation into the molecular mechanisms underlying stem cell pluripotency revealed that somatic cells could be reprogrammed to induced pluripotent stem cells (iPSCs) and these cells could be used to model Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, and Parkinson disease. Additional neural precursor and direct transdifferentiation strategies further enabled the induction of diverse neural linages and neuron subtypes both in vitro and in vivo. In this review, we highlight neural induction strategies that utilize stem cells, iPSCs, and lineage reprogramming to model or treat age-related neurodegenerative diseases, as well as, the clinical challenges related to neural transplantation and in vivo reprogramming strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.