Evidence map›Paper›PMID 26844738›Full record

ReviewContinuum (Minneapolis, Minn.)2016

Managing Epilepsy in Women.

Elizabeth E Gerard, Kimford J Meador

Open access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Continuum (Minneapolis, Minn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

  1. Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  2. Management of antiepileptic drug-induced nutrition-related adverse effects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Review
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  10. Effects of lacosamide "a novel antiepileptic drug" in the early stages of chicken embryo development.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Article
  11. Epilepsy during pregnancy: focus on management strategies.International journal of women's health · 2016
    Review
  12. Pregnancy and multiple sclerosis: Risk of unplanned pregnancy and drug exposure in utero.Multiple sclerosis journal - experimental, translational and clinical
    Article
  13. Women with epilepsy.Functional neurology
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth E Gerard
Kimford J Meador
Patient-Centered Outcomes Research Institute · US

Funding

Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)U01NS038455 · NINDS · STANFORD UNIVERSITY · PI MATTHEWS, ABIGAIL GOREN, MEADOR, KIMFORD J · 2012 to 2022
$27.7M
NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUGSR01NS038455 · NINDS · UNIVERSITY OF FLORIDA · PI MEADOR, KIMFORD J · 2000 to 2009
$12.0M
NINDS NIH HHS 2U01NS038455NINDS NIH HHS R01 NS038455NINDS NIH HHS U01 NS038455
6 · The paper itself

Abstract

purpose of reviewCaring for a woman with epilepsy requires familiarity with the implications of antiepileptic drugs (AEDs) for pregnancy and contraception as well as an understanding of the effects of female hormones on epilepsy. RECENT

findingsAED pregnancy registries and prospective studies of cognitive development continue to confirm that valproate poses a significantly increased risk of structural and cognitive teratogenesis. In contrast, data thus far suggest that lamotrigine and levetiracetam are associated with a relatively low risk for both anatomic and developmental adverse effects, although further studies are needed for these and other AEDs. The intrauterine device is a good contraceptive option for many women with epilepsy as it is highly effective and not subject to the drug-drug interactions seen between hormonal contraception and many AEDs. Hormonal-sensitive seizures are common among women with epilepsy; however, highly effective treatments for refractory catamenial seizures are limited. SUMMARY: Women with epilepsy should be counseled early and regularly about reproductive health as it relates to epilepsy. AED selection for women of childbearing age should take future pregnancies and contraceptive needs into consideration.

Indexed as

Disease ManagementAdultAnticonvulsantsEpilepsyFemaleHumansPregnancyPregnancy ComplicationsTeratogenesisVitaminsAnticonvulsantsVitamins

Identifiers

PMID26844738
PMCPMC8734579
OpenAlexW2372648669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.