Evidence map›Paper›PMID 26844702›Full record

ArticleCell death & disease2016

c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial-mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling.

X Xu, Y Zhu, Z Liang, S Li, X Xu, X Wang, J Wu, Z Hu, S Meng, B Liu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 108 citations in OpenAlex.

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  18. c-Met: A Promising Therapeutic Target in Bladder Cancer.Cancer management and research · 2022
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

X XuDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Y ZhuDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Z LiangDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
S LiDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
X XuDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
X WangDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
J WuDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Z HuDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
S MengDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
B LiuDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
J QinDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
L XieDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
X ZhengDepartment of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence has suggested that microRNAs (miRNAs) have an important role in tumor development and progression by regulating diverse cellular pathways. Here we describe the function and regulation network of miR-433 in bladder cancer (BCa). miR-433 is frequently downregulated in BCa tissues compared with adjacent non-cancerous tissues. Epigenetic mechanisms may be involved in the regulation of miR-433 expression. Enforced expression of miR-433 significantly inhibits proliferation, colony formation, migration, and invasion in BCa cells. In addition, miR-433 inhibits the epithelial-mesenchymal transition (EMT) in BCa cells by regulating c-Met/Akt/GSK-3β/Snail signaling pathway. Both c-Met and CREB1 are downstream target genes of miR-433. CREB1 can also indirectly regulate c-Met/Akt/GSK-3β/Snail signaling via MITF. Furthermore, CREB1 expression is an independent prognostic factor for overall survival in patients with BCa. Finally, there appears to exist a reciprocal regulation between c-Met and miR-433/miR-409-3p. Taken together, this study reveals that miR-433-c-MET/CREB1-Akt/GSK-3β/Snail signaling is critical to EMT in BCa. Targeting the pathway described here may open up new prospects to restrict metastatic progression of BCa.

Indexed as

Cyclic AMP Response Element-Binding ProteinDown-RegulationEpithelial-Mesenchymal TransitionGlycogen Synthase Kinase 3 betaHumansMicroRNAsOncogene Protein v-aktProto-Oncogene Proteins c-metSignal TransductionSnail Family Transcription FactorsTransfectionUrinary Bladder NeoplasmsCREB1 protein, humanCyclic AMP Response Element-Binding ProteinGlycogen Synthase Kinase 3 betaMicroRNAsMIRN433 microRNA, humanOncogene Protein v-aktProto-Oncogene Proteins c-metSnail Family Transcription Factors

Identifiers

PMID26844702
PMCPMC4849142
OpenAlexW2266996684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.