Evidence map›Paper›PMID 26844673›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

Lung Quality and Utilization in Controlled Donation After Circulatory Determination of Death Within the United States.

J J Mooney, H Hedlin, P K Mohabir, R Vazquez, J Nguyen, R Ha, P Chiu, K Patel, M R Zamora, D Weill and 2 more

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  4. Newly synthesized glycoprotein profiling to identify molecular signatures of warm ischemic injury in donor lungs.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  5. Article
  6. Ex-vivo lung perfusion therapies: do they add value to organ donation?Current opinion in organ transplantation · 2022
    Review
  7. Donation after circulatory death and lung transplantation.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022
    Review
  8. Review
  9. Predictors of nonuse of donation after circulatory death lung allografts.The Journal of thoracic and cardiovascular surgery · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

J J MooneyDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
H HedlinDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
P K MohabirDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
R VazquezDepartment of Medicine, University of New Mexico, Albuquerque, NM.
J NguyenDonor Network West, San Ramon, CA.
R HaDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA.
P ChiuDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA.
K PatelDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
M R ZamoraDepartment of Medicine, University of Colorado Health Sciences Center, Aurora, CO.
D WeillDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
M R NicollsDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.
G S DhillonDepartment of Medicine, Stanford University School of Medicine, Stanford, CA.

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationKL2TR001083 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$4.9M
Critical Role for Microvasculature in Airway TransplantationR01HL095686 · NHLBI · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI NICOLLS, MARK ROBERT · 2010 to 2022
$4.7M
Stanford Training Program in Lung BiologyT32HL129970 · NHLBI · STANFORD UNIVERSITY · PI CORNFIELD, DAVID N., NICOLLS, MARK ROBERT · 2016 to 2025
$3.2M
NCATS NIH HHS KL2 TR001083NHLBI NIH HHS HL095686NHLBI NIH HHS R01 HL095686NHLBI NIH HHS T32 HL129970
6 · The paper itself

Abstract

Although controlled donation after circulatory determination of death (cDCDD) could increase the supply of donor lungs within the United States, the yield of lungs from cDCDD donors remains low compared with donation after neurologic determination of death (DNDD). To explore the reason for low lung yield from cDCDD donors, Scientific Registry of Transplant Recipient data were used to assess the impact of donor lung quality on cDCDD lung utilization by fitting a logistic regression model. The relationship between center volume and cDCDD use was assessed, and the distance between center and donor hospital was calculated by cDCDD status. Recipient survival was compared using a multivariable Cox regression model. Lung utilization was 2.1% for cDCDD donors and 21.4% for DNDD donors. Being a cDCDD donor decreased lung donation (adjusted odds ratio 0.101, 95% confidence interval [CI] 0.085-0.120). A minority of centers have performed cDCDD transplant, with higher volume centers generally performing more cDCDD transplants. There was no difference in center-to-donor distance or recipient survival (adjusted hazard ratio 1.03, 95% CI 0.78-1.37) between cDCDD and DNDD transplants. cDCDD lungs are underutilized compared with DNDD lungs after adjusting for lung quality. Increasing transplant center expertise and commitment to cDCDD lung procurement is needed to improve utilization.

Indexed as

Blood CirculationBrain DeathAdultCaliforniaFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHumansIncidenceLungLung DiseasesLung TransplantationMaleMiddle AgedPostoperative Complicationsclinical researchdonation after circulatory death (DCD)donor evaluationdonors and donationdysfunctionlung (allograft) functionlung transplantationorgan procurementorgan procurement and allocationpracticepulmonologyScientific Registry for Transplant Recipients (SRTR)

Identifiers

PMID26844673
PMCPMC5086429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.