ArticleThe American journal of medicine2016
Objectively Measured Physical Activity and Symptoms Change in Knee Osteoarthritis.
Article in The American journal of medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Just-in-Time Adaptive Interventions for Behavior Change in Physiological Health Outcomes and the Use Case for Knee Osteoarthritis: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence.BMJ open · 2017Pooled it
- Trajectories of physical activity following digital education and exercise therapy-a longitudinal registry study among 15,197 persons with knee or hip osteoarthritis.BMC musculoskeletal disorders · 2026Article
- The Link Between Depression, Analgesia Usage and Function in Osteoarthritis: A Propensity Score-Matched Analysis from the Osteoarthritis Initiative Cohort.Bioengineering (Basel, Switzerland) · 2026Article
- Osteoarthritis: Mechanisms and Therapeutic Advances.MedComm · 2025Review
- Temporal Associations of Physical Activity With Subsequent Knee Pain in Individuals With Knee Osteoarthritis: An Ecological Momentary Assessment Study.European journal of pain (London, England) · 2025Article
- Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain.Frontiers in veterinary science · 2025Article
- Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats.Scientific reports · 2023Article
- Chondroprotective Effects of Chondrogenic Differentiated Adipose-Derived Mesenchymal Stem Cells Sheet on Degenerated Articular Cartilage in an Experimental Rabbit Model.Bioengineering (Basel, Switzerland) · 2023Article
- Effects of Combined Allogenic Adipose Stem Cells and Hyperbaric Oxygenation Treatment on Pathogenesis of Osteoarthritis in Knee Joint Induced by Monoiodoacetate.International journal of molecular sciences · 2022Article
- Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative.Clinical rheumatology · 2022Review
- Applications of Wearable Technology in a Real-Life Setting in People with Knee Osteoarthritis: A Systematic Scoping Review.Journal of clinical medicine · 2021Article
- Bidirectional associations of accelerometer measured sedentary behavior and physical activity with knee pain, stiffness, and physical function: The CARDIA study.Preventive medicine reports · 2021Article
- Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review.Clinical rheumatology · 2020Review
- Predictors of pain in general ageing populations: results from a multi-country analysis based on ATHLOS harmonized database.The journal of headache and pain · 2020Article
- Use of accelerometer-based activity monitoring in orthopaedics: benefits, impact and practical considerations.EFORT open reviews · 2019Review
- Modifiable risk factors in knee osteoarthritis: treatment implications.Rheumatology international · 2019Review
- Relationship between objectively measured lifestyle factors and health factors in patients with knee osteoarthritis: The STROBE Study.Medicine · 2019Article
- Understanding Atherosclerosis Through an Osteoarthritis Data Set.Arteriosclerosis, thrombosis, and vascular biology · 2019Review
- Responsiveness of Physical Activity Measures Following Exercise Programs after Total Knee Arthroplasty.Journal of exercise, sports & orthopedics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe study objective was to quantify the association between daily physical activity measured by accelerometer and 1-year changes in symptoms among people with knee osteoarthritis.
methodsParticipants from the Osteoarthritis Initiative had knee radiographs and physical activity assessed using GT1M ActiGraph (Pensacola, FL) uniaxial accelerometers at the 48-month visit. Physical activity was calculated and categorized as tertiles of average daily minutes in light and moderate-to-vigorous activity. Outcomes were 1-year change in symptoms measured by Western Ontario and McMaster Universities scales, including pain, stiffness, and physical function. Adjusted multivariable linear models estimated the relationship between tertiles of light or moderate-to-vigorous physical activity and changes in knee symptoms.
resultsAmong 1059 participants (55% were women; mean age, 66 ± 9 years), greater time in light activity was associated with a trend toward declined physical function (P = .01). Greater time in daily moderate-to-vigorous activity also was associated with declined physical function (P = .01) and increased pain (P = .08). None of these average changes in symptoms reached minimally important clinical differences. However, greater daily time in both activities was associated with a higher probability of worsening symptoms among persons with Kellgren-Lawrence grade 4 osteoarthritis.
conclusionsObjectively measured daily activity was not associated with 1-year symptom improvements among community-dwelling adults with knee osteoarthritis. In those with advanced disease (Kellgren-Lawrence grade 4), greater daily minutes in physical activity were associated with worsening symptoms. How best to implement exercise regimens in persons with advanced knee osteoarthritis to reduce the deleterious impact on symptoms needs to be explored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.