ReviewCurrent opinion in neurology2016
Considerations in biomarker development for neurodevelopmental disorders.
Review in Current opinion in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Peripheral Blood Monocytes as Biomarkers of Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.Research on child and adolescent psychopathology · 2025Pooled it
- Resting-state EEG power differences in autism spectrum disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Pooled it
- A single-blind active-control randomized controlled trial of group-based social competence intervention.Scientific reports · 2025Trial
- The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Trial
- Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Translational Study of Using FOCM/TS Metabolites for Supporting Autism Spectrum Disorder Diagnosis.Annals of biomedical engineering · 2026Article
- Toward preventive interventions in developmental coordination disorder: in need of early behavioral markers?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- PROTOCOL: Association of Antenatal Cytokine Concentrations With Neurodevelopmental Disorders of the Offspring: A Scoping Review.Campbell systematic reviews · 2025Article
- Autism Digital Phenotyping in Preschool- and School-Age Children.Autism research : official journal of the International Society for Autism Research · 2025Article
- fNIRS as a biomarker for X-linked neurodevelopmental disorders: leveraging visual processing to assess brain function?Frontiers in neuroscience · 2025Article
- Quantifying attention in children with intellectual and developmental disabilities through multicenter electrooculogram signal analysis.Scientific reports · 2024Article
- Eye-Tracking Biomarkers and Autism Diagnosis in Primary Care.JAMA network open · 2024Article
- Growth, body composition, and endocrine-metabolic profiles of individuals with Kleefstra syndrome provide directions for clinical management and translational studies.American journal of medical genetics. Part A · 2024Article
- Intervention Effect of Group Sensory Integration Training on Social Responsiveness and N170 Event-Related Potential of Children with Autism.Behavioral sciences (Basel, Switzerland) · 2024Article
- EEG Biomarkers for Autism: Rational, Support, and the Qualification Process.Advances in neurobiology · 2024Review
- Face processing in young adults with autism and ADHD: An event related potentials study.Frontiers in psychiatry · 2023Article
- Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment.Frontiers in psychiatry · 2023Article
- Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia.Review journal of autism and developmental disorders · 2022Article
- Autism Spectrum as an Etiologic Systemic Disorder: A Protocol for an Umbrella Review.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purpose of reviewDespite significant progress in recognizing the biological bases of autism spectrum disorder, diagnosis and treatment rely primarily on subjective evaluation of behavior. This review highlights the challenges unique to neurodevelopmental disorders that have limited biomarker development. RECENT
findingsThe field of neurodevelopmental disorders requires objective quantification of biological processes to enable designation of subgroups likely to benefit from specific treatments, index diagnostic status/risk, demonstrate engagement of targeted systems, and provide more rapid assessment of change than traditional clinical observation and caregiver report measures. SUMMARY: Useful biomarkers for neurodevelopmental disorders must be reliable across development, evident at the individual level, and specific to a unit of analysis, be it diagnostic status or functional process. The ultimate value of biomarkers for neurodevelopmental disorders will relate to their ease of use, cost, scalability, sensitivity, and methodological objectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.