ArticlePloS one2016
The Influence of a Metal Stent on the Distribution of Thermal Energy during Irreversible Electroporation.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Influence of Irreversible Electroporation Parameters on the Size of the Ablation Zone and Thermal Effects: A Systematic Review.Technology in cancer research & treatmentPooled it
- Pulsed electric field ablation process-the effect of bifurcation stents on electric field and heat distribution.Scientific reports · 2025Article
- Toward Large Ablations With Single-Needle High-Frequency Irreversible Electroporation In Vivo.IEEE transactions on bio-medical engineering · 2025Article
- Feasibility study of intravascular pulsed electric field ablation for the treatment of cardiac arrhythmias.Frontiers in physiology · 2025Article
- Pulsed electric field ablation process-a study of the effect of different shapes (materials) of metal stents on the ablation effect.Frontiers in cardiovascular medicine · 2025Article
- Epicardial pulsed-field ablation-impact of electric field and heat distribution induced by coronary metallic stents.Frontiers in cardiovascular medicine · 2024Article
- Article
- Endovenous radiofrequency ablation using a new bipolar electrode in a canine model: a new endovenous radiofrequency electrode.Annals of surgical treatment and research · 2023Article
- In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation.Journal of cardiovascular development and disease · 2022Article
- Real-Time Temperature Rise Estimation during Irreversible Electroporation Treatment through State-Space Modeling.Bioengineering (Basel, Switzerland) · 2022Article
- Investigation of safety for electrochemotherapy and irreversible electroporation ablation therapies in patients with cardiac pacemakers.Biomedical engineering online · 2020Article
- Effect of irreversible electroporation parameters and the presence of a metal stent on the electric field line pattern.Scientific reports · 2020Article
- Recent progress in pulsed electric field ablation for liver cancer.World journal of gastroenterology · 2020Review
- Safety, Efficacy, and Technical Details of Endoscopic Retrograde Cholangiopancreatography After Irreversible Electroporation for Locally Advanced Pancreatic Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Thermodynamic profiling during irreversible electroporation in porcine liver and pancreas: a case study series.Journal of clinical and translational research · 2020Article
- Preliminary results in unresectable cholangiocarcinoma treated by CT percutaneous irreversible electroporation: feasibility, safety and efficacy.Medical oncology (Northwood, London, England) · 2020Article
- Peri-tumoral Metallic Implants Reduce the Efficacy of Irreversible Electroporation for the Ablation of Colorectal Liver Metastases.Cardiovascular and interventional radiology · 2020Article
- Locally Advanced Pancreatic Cancer: Work-Up, Staging, and Local Intervention Strategies.Cancers · 2019Review
- Conductivity Rise During Irreversible Electroporation: True Permeabilization or Heat?Cardiovascular and interventional radiology · 2018Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIrreversible electroporation (IRE) uses short duration, high-voltage electrical pulses to induce cell death via nanoscale defects resulting from altered transmembrane potential. The technique is gaining interest for ablations in unresectable pancreatic and hepatobiliary cancer. Metal stents are often used for palliative biliary drainage in these patients, but are currently seen as an absolute contraindication for IRE due to the perceived risk of direct heating of the metal and its surroundings. This study investigates the thermal and tissue viability changes due to a metal stent during IRE.
methodsIRE was performed in a homogeneous tissue model (polyacrylamide gel), without and with a metal stent placed perpendicular and parallel to the electrodes, delivering 90 and 270 pulses (15-35 A, 90 μsec, 1.5 cm active tip exposure, 1.5 cm interelectrode distance, 1000-1500 V/cm, 90 pulses/min), and in-vivo in a porcine liver (4 ablations). Temperature changes were measured with an infrared thermal camera and with fiber-optic probes. Tissue viability after in-vivo IRE was investigated macroscopically using 5-triphenyltetrazolium chloride (TTC) vitality staining.
resultsIn the gel, direct stent-heating was not observed. Contrarily, the presence of a stent between the electrodes caused a higher increase in median temperature near the electrodes (23.2 vs 13.3°C [90 pulses]; p = 0.021, and 33.1 vs 24.8°C [270 pulses]; p = 0.242). In-vivo, no temperature difference was observed for ablations with and without a stent. Tissue examination showed white coagulation 1mm around the electrodes only. A rim of vital tissue remained around the stent, whereas ablation without stent resulted in complete tissue avitality.
conclusionIRE in the vicinity of a metal stent does not cause notable direct heating of the metal, but results in higher temperatures around the electrodes and remnant viable tissue. Future studies should determine for which clinical indications IRE in the presence of metal stents is safe and effective.
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