Evidence map›Paper›PMID 26844363›Full record

ArticleRadiology2016

An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging.

Emad Ahmadi, Husam A Katnani, Laleh Daftari Besheli, Qiang Gu, Reza Atefi, Martin Y Villeneuve, Emad Eskandar, Michael H Lev, Alexandra J Golby, Rajiv Gupta and 1 more

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Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emad AhmadiFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Husam A KatnaniFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Laleh Daftari BesheliFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Qiang GuFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Reza AtefiFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Martin Y VilleneuveFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Emad EskandarFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Michael H LevFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Alexandra J GolbyFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Rajiv GuptaFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).
Giorgio BonmassarFrom the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.).

Funding

Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
High-Field MR Compatible Dense Array EEG using Polymer Thick Film TechnologyR44NS071988 · NINDS · ELECTRICAL GEODESICS, INC. · PI POULSEN, CATHERINE · 2014 to 2016
$1.7M
Deep Brain Stimulation System for Magnetic Resonance ImagingU01NS075026 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BONMASSAR, GIORGIO, ESKANDAR, EMAD N · 2013 to 2015
$1.1M
High-Field MR-Compatible Dense Array EEG using Polymer Thick Film TechnologyR43NS071988 · NINDS · ELECTRICAL GEODESICS, INC. · PI POULSEN, CATHERINE · 2010 to 2011
$703k
The Virtual Patient Simulator of Patients with Deep Brain Stimulation ImplantsR21EB016449 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BONMASSAR, GIORGIO, MAKRIS, NIKOLAOS · 2013 to 2014
$465k
NCRR NIH HHS P41 RR014075NIBIB NIH HHS P41 EB015898NIBIB NIH HHS R21 EB016449NINDS NIH HHS R43 NS071988NINDS NIH HHS R44 NS071988NINDS NIH HHS U01 NS075026
6 · The paper itself

Abstract

Purpose To develop an electrocorticography (ECoG) grid by using deposition of conductive nanoparticles in a polymer thick film on an organic substrate (PTFOS) that induces minimal, if any, artifacts on computed tomographic (CT) and magnetic resonance (MR) images and is safe in terms of tissue reactivity and MR heating. Materials and Methods All procedures were approved by the Animal Care and Use Committee and complied with the Public Health Services Guide for the Care and Use of Animals. Electrical functioning of PTFOS for cortical recording and stimulation was tested in two mice. PTFOS disks were implanted in two mice; after 30 days, the tissues surrounding the implants were harvested, and tissue injury was studied by using immunostaining. Five neurosurgeons rated mechanical properties of PTFOS compared with conventional grids by using a three-level Likert scale. Temperature increases during 30 minutes of 3-T MR imaging were measured in a head phantom with no grid, a conventional grid, and a PTFOS grid. Two neuroradiologists rated artifacts on CT and MR images of a cadaveric head specimen with no grid, a conventional grid, and a PTFOS grid by using a four-level Likert scale, and the mean ratings were compared between grids. Results Oscillatory local field potentials were captured with cortical recordings. Cortical stimulations in motor cortex elicited muscle contractions. PTFOS implants caused no adverse tissue reaction. Mechanical properties were rated superior to conventional grids (χ(2) test, P < .05). The temperature increase during MR imaging for the three cases of no grid, PTFOS grid, and conventional grid was 3.84°C, 4.05°C, and 10.13°C, respectively. PTFOS induced no appreciable artifacts on CT and MR images, and PTFOS image quality was rated significantly higher than that with conventional grids (two-tailed t test, P < .05). Conclusion PTFOS grids may be an attractive alternative to conventional ECoG grids with regard to mechanical properties, 3-T MR heating profile, and CT and MR imaging artifacts. (©) RSNA, 2016 Online supplemental material is available for this article.

Indexed as

Magnetic Resonance ImagingPolymersTomography, X-Ray ComputedAnimalsArtifactsBrainElectrocorticographyHeadHumansMiceModels, AnimalNanoparticlesPhantoms, ImagingReproducibility of ResultsPolymers

Identifiers

PMID26844363
PMCPMC4949083

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