ArticleAsia Pacific allergy2016
A stepwise approach in the management of chronic spontaneous urticaria in children.
Article in Asia Pacific allergy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Managing Chronic Urticaria in Children: An Update.Current allergy and asthma reports · 2025Review
- Comorbidities of Chronic Urticaria: A glimpse into a complex relationship.Frontiers in allergy · 2022Review
- Pharmacologic Management of Chronic Urticaria in Pediatric Patients: The Gap Between Guidelines and Practice.Paediatric drugs · 2020Review
- Care for children with severe chronic skin diseases.European journal of pediatrics · 2019Article
- Chronic Urticaria: An Overview of Treatment and Recent Patents.Recent patents on inflammation & allergy drug discovery · 2019Review
- High-dose anti-histamine use and risk factors in children with urticaria.Turk pediatri arsivi · 2016Article
- Asia Pacific Allergy: it's been five years!Asia Pacific allergy · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited literature in the management of chronic urticaria in children. Treatment algorithms are generally extrapolated from adult studies.
objectiveUtility of a weight and age-based algorithm for antihistamines in management of chronic spontaneous urticaria (CSU) in childhood. To document associated factors that predict for step of control of CSU and time taken to attain control of symptoms in children.
methodsA workgroup comprising of allergists, nurses, and pharmacists convened to develop a stepwise treatment algorithm in management of children with CSU. Sequential patients presenting to the paediatric allergy service with CSU were included in this observational, prospective study.
resultsNinety-eight patients were recruited from September 2012 to September 2013. Majority were male, Chinese with median age 4 years 7 months. A third of patients with CSU had a family history of acute urticaria. Ten point two percent had previously resolved CSU, 25.5% had associated angioedema, and 53.1% had a history of atopy. A total of 96.9% of patients achieved control of symptoms, of which 91.8% achieved control with cetirizine. Fifty percent of all the patients were controlled on step 2 or higher. Forty-seven point eight percent of those on step 2 or higher were between 2 to 6 years of age compared to 32.6% and 19.6% who were 6 years and older and lesser than 2 years of age respectively. Eighty percent of those with previously resolved CSU required an increase to step 2 and above to achieve chronic urticaria control.
conclusionWe propose a weight- and age-based titration algorithm for different antihistamines for CSU in children using a stepwise approach to achieve control. This algorithm may improve the management and safety profile for paediatric CSU patients and allow for review in a more systematic manner for physicians dealing with CSU in children.
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